EC Number   |
Natural Substrates |
|---|
    2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
regulation of isoprenoid synthesis and metabolism |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
enzyme involved in ketone body production, control of hepatic fatty acid oxidation, potential control point for ketogenesis |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
pathway of ketogenesis in the mitochondria, mevalonate synthesis in the cytoplasm |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
key role in synthesis of various sterols and isoprenoids |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
major cytoplasmic synthase, synthase II is implicated in cholesterol synthesis |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
acetoacetate biosynthesis, 3-hydroxy-3-methylglutaryl-CoA pathway |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
mevalonate pathway |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
potentially favorable position for the regulation of hepatic ketogenesis |
| 2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O |
second enzyme in the cytoplasmic mevalonate pathway of isoprenoid biosynthesis |
