EC Number   |
Natural Substrates |
|---|
    1.14.15.18 | 25-hydroxyvitamin D + NADPH + O2 |
deficiency of the enzyme, due to mutation of residues Q65 and T409, in substrate binding causes vitamin D-dependent rickets type 1, overview |
| 1.14.15.18 | 25-hydroxyvitamin D + NADPH + O2 |
extra-renal functions of 1alpha-hydroxylase in vitamin D physiology, regulation, overview |
| 1.14.15.18 | 25-hydroxyvitamin D + NADPH + O2 |
regulation of enzyme expression in kidney proximal tubules, overview |
| 1.14.15.18 | 25-hydroxyvitamin D + NADPH + O2 |
substrate activation by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma, in pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)2D3 and hypercalcemia |
| 1.14.15.18 | 25-hydroxyvitamin D + NADPH + O2 |
the enzyme hydroxylates the major circulating form of vitamin D to the active systemic hormone 1,25(OH)2D3, local production of 1,25(OH)2D3 appears to occur also at other sites where 1alpha-hydroxylase is expressed for autocrine/paracrine regulation, overview |
| 1.14.15.18 | 25-hydroxyvitamin D + NADPH + O2 |
the enzyme is involved in the vitamin D signaling pathway in colonic epithelial cell differentiation by butyrate, mechanism, overview |
| 1.14.15.18 | 25-hydroxyvitamin D + NADPH + O2 |
the enzyme is responsible for final hydroxylation of vitamin D3, in response to IFNgamma and CD14/TLR4 activation |
| 1.14.15.18 | 25-hydroxyvitamin D2 + NADPH + H+ + O2 |
- |
| 1.14.15.18 | 25-hydroxyvitamin D3 + H+ + O2 |
- |
| 1.14.15.18 | 25-hydroxyvitamin D3 + NADPH + H+ + O2 |
- |
