EC Number |
Metals/Ions |
Reference |
---|
6.3.2.2 | Mg2+ |
- |
1126, 650713, 651896, 690385, 690440, 690630, 691909, 691912, 692055, 692058, 692442, 692444, 694060, 694485, 694609, 694674 |
6.3.2.2 | Cu2+ |
2 divalent metal ions per enzyme molecule are bound, can be replaced by Mn2+ and Mg2+, binding mechanism and kinetics, overview |
652341 |
6.3.2.2 | Mn2+ |
2 divalent metal ions per enzyme molecule are bound, Mg2+ broadens the substrate specificity, decreases the resistance to L-buthionine-S,R-sulfoximine, can be replaced by Mg2+ and Cu2+, binding mechanism and kinetics, overview |
652341 |
6.3.2.2 | Mg2+ |
2 divalent metal ions per enzyme molecule are bound, Mg2+ sharpens the substrate specificity, increases the resistance to L-buthionine-S,R-sulfoximine, can be replaced by Mn2+ and Cu2+, binding mechanism and kinetics, overview |
652341 |
6.3.2.2 | K+ |
absolute requirement for Mg2+, Mn2+, and K+ ions |
706061 |
6.3.2.2 | Mg2+ |
absolute requirement for Mg2+, Mn2+, and K+ ions |
706061 |
6.3.2.2 | Mn2+ |
absolute requirement for Mg2+, Mn2+, and K+ ions |
706061 |
6.3.2.2 | Mg2+ |
absolute requirement, maximal activity at 30-50 mM |
1149 |
6.3.2.2 | As3+ |
As3+ coordinately upregulates GCL catalytic subunit and GCL modifier subunit mRNA levels resulting in increased GCL subunit protein expression, holoenzyme formation, and activity. As3+ increases the rate of transcription of both the GCL catalytic subunit and GCL modifier subunit genes and induces the posttranscriptional stabilization of GCL modifier subunit mRNA. The antioxidant N-acetylcysteine abolishes As3+-induced GCL catalytic subunit expression and attenuates induction of GCL modifier subunit. As3+ induction of GCL catalytic subunit and GCL modifier subunit is also differentially regulated by the MAPK signaling pathways and occurrs independent of the Nrf1/2 transcription factors |
703807 |
6.3.2.2 | Mn2+ |
bound to the erythrocyte enzyme |
649263 |