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EC Number	Metals/Ions	Commentary	Reference
2.7.8.13	Mg2+	-	645332, 645335
2.7.8.13	Mg2+	absolute requirement for divalent cations, optimal activity with Mg2+ at concentrations 40-75 mM	662239
2.7.8.13	Mg2+	absolute requirement, maximun activity at 30-40 mM	645334
2.7.8.13	Mg2+	can be replaced only by Mn2+	645340
2.7.8.13	Mn2+	can substitute for Mg2+	645334
2.7.8.13	Mg2+	catalytic activity is dependent on Mg2+	725566
2.7.8.13	more	Cu2+, Ca2+ and Zn2+ are without effect	645334
2.7.8.13	Mn2+	enzyme activity in presence of Mn2+ is 1% of the activity detected in presence of Mg2+	662239
2.7.8.13	Mg2+	essentially required	737788
2.7.8.13	more	no activity is observed using Ni2+, Ca2+ and Zn2+	645340

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Release 2023.1 (January 2023)