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Information on EC 2.7.8.13 - phospho-N-acetylmuramoyl-pentapeptide-transferase
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2.7.8.13 phospho-N-acetylmuramoyl-pentapeptide-transferaseIUBMB Comments
In Gram-negative and some Gram-positive organisms the L-lysine is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm), which is combined with adjacent residues through its L-centre. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here).
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Word Map
- 2.7.8.13
- peptidoglycan
- capuramycins
- udp-murnac-pentapeptide
-
muraymycins
-
mureidomycins
- medicine
-
pacidamycins
-
caprazamycins
- drug development
- molecular biology
- analysis
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
translocase i, translocase 1, phospho-murnac-pentapeptide translocase, mray translocase, phospho-n-acetylmuramyl-pentapeptide translocase, mray transferase, mray protein, phospho-n-acetylmuramoyl-pentapeptide translocase, phospho-n-acetyl-muramyl-pentapeptide translocase, phospho-n-acetylmuramoyl-pentapeptide-transferase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
MraY
MraY protein
MraY transferase
MraY translocase
phospho-MurNAc-pentapeptide transferase
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phospho-MurNAc-pentapeptide translocase
phospho-N-acetylmuramoyl pentapeptide translocase
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phospho-N-acetylmuramoyl-pentapeptide translocase
phospho-N-acetylmuramoylpentapeptidetransferase
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phospho-N-acetylmuramyl-pentapeptide translocase
phospho-NAc-muramoyl-pentapeptide translocase (UMP)
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phosphoacetylmuramoylpentapeptide translocase
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phosphoacetylmuramoylpentapeptidetransferase
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polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase
translocase I
translocase-I
UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase
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UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase
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MraY transferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
in gram-negative and some gram-positive organisms the L-lysine is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm), which is combined with adjacent residues through its L-centre. The undecaprenol involved is ditrans, octacis-undecaprenol
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UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
a one-step, single displacement mechanism. The oxyanion of the polyprenyl-phosphate attacks the b-phosphate of the nucleotide substrate, leading to the formation of product lipid I and liberation of UMP. The involvement of an invariant aspartyl residue in the deprotonation of the lipid substrate is possible. Formation of a covalent reaction intermediate
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
a one-step, single displacement mechanism. The oxyanion of the polyprenyl-phosphate attacks the b-phosphate of the nucleotide substrate, leading to the formation of product lipid I and liberation of UMP. The involvement of an invariant aspartyl residue in the deprotonation of the lipid substrate is possible. Formation of a covalent reaction intermediate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
substituted phospho group transfer
substituted phospho group transfer
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase
In Gram-negative and some Gram-positive organisms the L-lysine is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm), which is combined with adjacent residues through its L-centre. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here).
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CAS REGISTRY NUMBER
COMMENTARY
9068-50-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dansyl-UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + dansyl-UDP-NAc-muramoyl-pentapeptide-diphosphoundecaprenol
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-
-
-
?
N-dansyl-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
N-fluorescamine-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
N-o-phthalaldehyde-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala) + dodecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala)-diphosphododecaprenol
UDP-MurNAc-(oyl-L-Ala) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala)-diphosphoundecaprenol
UDP-MurNAc-(oyl-L-Ala-gamma-D-Glu) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu)-diphosphoundecaprenol
36% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
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r
UDP-MurNAc-(oyl-L-Ala-gamma-D-Glu-meso-diaminopimelate) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-diaminopimelate)-diphosphoundecaprenol
51% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
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r
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-Gly + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-Gly-diphosphoundecaprenol
-
-
-
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?
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-Gly-D-Ala-diphosphoundecaprenol
-
-
-
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?
UDP-MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala-diphosphoundecaprenol
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-
-
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?
UDP-MurNAc-Ala-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-Glu-Lys-diphosphoundecaprenol
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-
-
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?
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala-diphosphoundecaprenol
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-
-
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?
UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + C55-isoprenyl phosphate
C55-isoprenyl-diphosphate-MurNAc-pentapeptide
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + undecaprenol diphosphate N-acetylmuramyl pentapeptide
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30 min, 35°C, pH 7.5
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?
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP-N-acetylmuramoyl-pentapeptide + undecaprenyl phosphate
?
-
a homogeneous fluorescence resonance energy transfer (FRET)-based assay for the translocase activity of MraY in which the donor fluorophore is attached to UNAM-pp and the acceptor is embedded in detergent micelles containing MraY and undecaprenyl phosphate is described
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?
UDP-N-acetylmuramoyl-pentapeptide + undecaprenyl phosphate
UMP + N-acetylmuramoyl-pentapeptide-diphosphoundecaprenol
25°C, pH 7.2
lipid I synthesis, peptidoglycan biosynthesis
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?
UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
UDP-NAc-muramoyl-pentapeptide + dodecaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
UDP-NAc-muramoyl-pentapeptide + heptaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
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r
UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + undecaprenyl-phospho-NAc-muramoyl-pentapeptide
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
N-dansyl-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
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-
-
-
?
N-dansyl-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
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?
N-fluorescamine-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
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-
-
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?
N-fluorescamine-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
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-
-
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?
N-o-phthalaldehyde-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
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-
-
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?
N-o-phthalaldehyde-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
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?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
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r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
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r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
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r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step in biosynthesis of bacterial cell wall peptidoglycan
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-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
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r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
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catalyzes the first of a sequence of lipid-linked steps that ultimately assemble the peptidoglycan layer of the bacterial cell wall
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?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
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r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
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r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
the forward and reverse exchange reactions require the presence of the second substrate, undecaprenyl phosphate and UMP, respectively. No activity is detected with isopentenyl phosphate, but the enzyme is highly active with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
the forward and reverse exchange reactions require the presence of the second substrate, undecaprenyl phosphate and UMP, respectively. No activity is detected with isopentenyl phosphate, but the enzyme is highly active with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc + undecaprenyl phosphate
UMP + MurNAc-diphosphoundecaprenol
24% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc + undecaprenyl phosphate
UMP + MurNAc-diphosphoundecaprenol
24% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala) + dodecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala)-diphosphododecaprenol
-
dPP
-
r
UDP-MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala) + dodecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala)-diphosphododecaprenol
-
dPP
-
r
UDP-MurNAc-(oyl-L-Ala) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala)-diphosphoundecaprenol
9% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc-(oyl-L-Ala) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala)-diphosphoundecaprenol
9% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
-
inhibitory assay
-
-
?
UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
-
inhibitory assay
-
-
?
UDP-MurNAc-pentapeptide + C55-isoprenyl phosphate
C55-isoprenyl-diphosphate-MurNAc-pentapeptide
-
-
-
r
UDP-MurNAc-pentapeptide + C55-isoprenyl phosphate
C55-isoprenyl-diphosphate-MurNAc-pentapeptide
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit
-
-
r
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
Lipid I precursor synthesis, murein biosynthesis
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
efficient complementation of enzymatic activity in bacterial strain lacking endogenous MraY
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
-
Lipid I precursor synthesis, murein biosynthesis
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
natural acceptor
-
-
r
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
-
-
?
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
Priestia megaterium KM / ATCC 13632
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
Priestia megaterium KM / ATCC 13632
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
equilibrium constant 0.25
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
equilibrium constant 0.25
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + dodecaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
dodecaprenyl phosphate is a more efficient substrate than heptaprenyl-phosphate, enzyme is selective for larger substrate which is closer in chain length to the natural substrate, undecaprenyl-phosphate
-
r
UDP-NAc-muramoyl-pentapeptide + dodecaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
dodecaprenyl phosphate is a more efficient substrate than heptaprenyl-phosphate, enzyme is selective for larger substrate which is closer in chain length to the natural substrate, undecaprenyl-phosphate
-
r
UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + undecaprenyl-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + undecaprenyl-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
r
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
additional information
?
-
all five cytoplasmic segments contribute to catalytic site with at least 14 invariant polar and/or charged, non-clustered residues, conserved residue D98 supposedly involved in deprotonation of lipid substrate during catalysis at physiological pH 7.4 (pKa for undecaprenyl phosphate: 6.6 and 9.2)
-
-
?
additional information
?
-
-
all five cytoplasmic segments contribute to catalytic site with at least 14 invariant polar and/or charged, non-clustered residues, conserved residue D98 supposedly involved in deprotonation of lipid substrate during catalysis at physiological pH 7.4 (pKa for undecaprenyl phosphate: 6.6 and 9.2)
-
-
?
additional information
?
-
functional complementation in a MraY-lacking, thermosensitive Escherichia coli mutant strain (2fold increased UDP-N-acetylmuramoyl-pentapeptide level compared to wild-type cells when grown 30 min at 42°C, depletion of lipid I) by overexpression of wild-type or mutants E299Q, D177N, N168A, H45R, K48Q, H291R
-
-
?
additional information
?
-
-
functional complementation in a MraY-lacking, thermosensitive Escherichia coli mutant strain (2fold increased UDP-N-acetylmuramoyl-pentapeptide level compared to wild-type cells when grown 30 min at 42°C, depletion of lipid I) by overexpression of wild-type or mutants E299Q, D177N, N168A, H45R, K48Q, H291R
-
-
?
additional information
?
-
assay method development for high-throughput screening assays and metadata annotation, overview
-
-
?
additional information
?
-
the enzyme does not display any diphosphatase activity on the nucleotide substrate. No activity with UDP-GlcNAc and 1-diphospho-MurNAc-pentapeptide. Enzyme catalytic mechanism and substrate specificity, overview. The essential aspartate residue, that is invariant in the superfamily, is Asp98 in Bacillus subtilis MraY, the residue is involved in the deprotonation of the lipid substrate during the catalytic process. UDPMurNAc, UDP-MurNAc-L-Ala, UDP-MurNAc-L-Ala-D-Glu and UDPMurNAc-L-Ala-gamma-D-Glu-meso-diaminopimelate precursors of the peptidoglycan biosynthesis pathway are all substrates of the enzyme, no activity with 1-diphospho-MurNAc-pentapeptide. No activity with isopentenyl phosphate as lipid substrate, the enzyme is highly active when tested with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
?
additional information
?
-
-
the enzyme does not display any diphosphatase activity on the nucleotide substrate. No activity with UDP-GlcNAc and 1-diphospho-MurNAc-pentapeptide. Enzyme catalytic mechanism and substrate specificity, overview. The essential aspartate residue, that is invariant in the superfamily, is Asp98 in Bacillus subtilis MraY, the residue is involved in the deprotonation of the lipid substrate during the catalytic process. UDPMurNAc, UDP-MurNAc-L-Ala, UDP-MurNAc-L-Ala-D-Glu and UDPMurNAc-L-Ala-gamma-D-Glu-meso-diaminopimelate precursors of the peptidoglycan biosynthesis pathway are all substrates of the enzyme, no activity with 1-diphospho-MurNAc-pentapeptide. No activity with isopentenyl phosphate as lipid substrate, the enzyme is highly active when tested with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
?
additional information
?
-
assay method development for high-throughput screening assays and metadata annotation, overview
-
-
?
additional information
?
-
the enzyme does not display any diphosphatase activity on the nucleotide substrate. No activity with UDP-GlcNAc and 1-diphospho-MurNAc-pentapeptide. Enzyme catalytic mechanism and substrate specificity, overview. The essential aspartate residue, that is invariant in the superfamily, is Asp98 in Bacillus subtilis MraY, the residue is involved in the deprotonation of the lipid substrate during the catalytic process. UDPMurNAc, UDP-MurNAc-L-Ala, UDP-MurNAc-L-Ala-D-Glu and UDPMurNAc-L-Ala-gamma-D-Glu-meso-diaminopimelate precursors of the peptidoglycan biosynthesis pathway are all substrates of the enzyme, no activity with 1-diphospho-MurNAc-pentapeptide. No activity with isopentenyl phosphate as lipid substrate, the enzyme is highly active when tested with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
?
additional information
?
-
-
UDP-N-acetylmuramyl-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanyl-D-alanine: Parks nucleotide, UDP-MurNAc-pentapeptide
-
-
?
additional information
?
-
-
catalyzes an exchange reaction between UMP and UDP-MurNAc-pentapeptide in the absence of undecaprenyl phosphate
-
-
?
additional information
?
-
-
catalyzes an exchange reaction between UMP and UDP-MurNAc-pentapeptide in the absence of undecaprenyl phosphate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step in biosynthesis of bacterial cell wall peptidoglycan
-
-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first of a sequence of lipid-linked steps that ultimately assemble the peptidoglycan layer of the bacterial cell wall
-
-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2A