EC Number |
Metals/Ions |
Reference |
---|
1.13.11.34 | Ca2+ |
- |
684399, 688512, 689841 |
1.13.11.34 | Fe2+ |
- |
704997 |
1.13.11.34 | Mg2+ |
- |
689841 |
1.13.11.34 | Ca2+ |
0.1 mM |
676811 |
1.13.11.34 | Ba2+ |
45% of the activation with Ca2+ |
439461 |
1.13.11.34 | Mg2+ |
5 mM activates 5LO in vitro in the presence of PC |
676811 |
1.13.11.34 | Ca2+ |
5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+ |
659654 |
1.13.11.34 | Ca2+ |
5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+. Ca2+ and 5-lipoxygenase phosphorylation seem to be required for arachidonic acid-induced 5-lipoxygenase product formation |
659654 |
1.13.11.34 | Ca2+ |
5-LOX is recruited to the nuclear membrane upon cellular Ca2+ influx. Calcium binds to allosteric sites in the 5-LOX N-terminal polycystin-1/lipoxygenase/alpha-toxin (PLAT) domain, promoting attachment to the membrane via conserved tryptophan residues that embed into the lipid bilayer |
741898 |
1.13.11.34 | Fe2+ |
a non-heme iron dioxygenase |
741918 |