EC Number   |
Metals/Ions  |
Reference |
|---|
    1.13.11.34 | 1-oleoyl-2-acetyl-sn-glycerol |
both Ca2+ and glyceride, e.g. 1-oleoyl-2-acetyl-sn-glycerol, might decrease the concentration of lipid hydroperoxide needed for activation of 5-LO, enabling cellular 5-LO product formation at a low redox tone |
690170 |
| 1.13.11.34 | Ba2+ |
45% of the activation with Ca2+ |
439461 |
| 1.13.11.34 | Ca2+ |
- |
684399, 688512, 689841 |
| 1.13.11.34 | Ca2+ |
0.1 mM |
676811 |
| 1.13.11.34 | Ca2+ |
5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+ |
659654 |
| 1.13.11.34 | Ca2+ |
5-lipoxygenase product formation in arachidonic acid-stimulated polymorphonuclear leukocytes is independent of Ca2+. Ca2+ and 5-lipoxygenase phosphorylation seem to be required for arachidonic acid-induced 5-lipoxygenase product formation |
659654 |
| 1.13.11.34 | Ca2+ |
5-LOX is recruited to the nuclear membrane upon cellular Ca2+ influx. Calcium binds to allosteric sites in the 5-LOX N-terminal polycystin-1/lipoxygenase/alpha-toxin (PLAT) domain, promoting attachment to the membrane via conserved tryptophan residues that embed into the lipid bilayer |
741898 |
| 1.13.11.34 | Ca2+ |
above 0.1 mM, required for maximal activity |
439438 |
| 1.13.11.34 | Ca2+ |
activates |
684672, 704997, 711134 |
| 1.13.11.34 | Ca2+ |
activates, Ca2+ induces the translocation of 5-LO from a soluble compartment to nuclear structures, where 5-LO co-localizes with 5-LO activating protein, FLAP |
689872 |
