Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | about half as active as ATP | Rattus norvegicus | |
AMP | about half as active as ATP | Rattus norvegicus | |
ATP | stimulates | Rattus norvegicus | |
CTP | about half as active as ATP | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | 0.01 mM, 34% inhibition | Rattus norvegicus | |
5,8,11,13-eicosatetraynoic acid | IC50: 0.028 mM | Rattus norvegicus | |
8-hydroxyquinoline | 0.01 mM, 59% inhibition | Rattus norvegicus | |
AA861 | IC50: 0.0026 mM | Rattus norvegicus | |
baicalein | IC50: 0.0012 mM | Rattus norvegicus | |
BW755C | CAS: 66000-40-6; IC50: 0.53 MM | Rattus norvegicus | |
caffeic acid | IC50: 0.046 mM | Rattus norvegicus | |
catechol | IC50: 0.062 mM | Rattus norvegicus | |
Cirsiliol | IC50: 0.098 mM | Rattus norvegicus | |
epinephrine | IC50: 0.98 mM | Rattus norvegicus | |
esculetin | IC50: 0.0045 mM | Rattus norvegicus | |
eupatilin | IC50: 0.098 mM | Rattus norvegicus | |
indomethacin | IC50: 0.36 mM | Rattus norvegicus | |
iodoacetamide | 0.01 mM, 20% inhibition | Rattus norvegicus | |
NEM | 0.01 mM, 75% inhibition | Rattus norvegicus | |
nordihydroguiaraetic acid | IC50: 0.00021 mM | Rattus norvegicus | |
norepinephrine | IC50: 0.49 mM | Rattus norvegicus | |
quercetin | IC50: 0.0021 mM | Rattus norvegicus | |
rutin | IC50: 0.033 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
arachidonic acid | - |
Rattus norvegicus | |
0.024 | - |
5,8,11,14,17-eicosapentaenoic acid | - |
Rattus norvegicus | |
0.032 | - |
5,8,11-eicosatrienoic acid | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ba2+ | 45% of the activation with Ca2+ | Rattus norvegicus | |
Ca2+ | required | Rattus norvegicus | |
Ca2+ | half-maximal activity at 0.1 mM | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | - |
Rattus norvegicus | - |
Storage Stability | Organism |
---|---|
4°C, 48 h, no appreciable loss of activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,8,11,14,17-eicosapentaenoic acid + O2 | - |
Rattus norvegicus | ? | - |
? | |
5,8,11-eicosatrienoic acid + O2 | almost as active as arachidonic acid | Rattus norvegicus | ? | - |
? | |
8,11,14-eicosatrienoic acid + O2 | - |
Rattus norvegicus | ? | - |
? | |
arachidonate + O2 | i.e. 5,8,11,14-eicosatetraenoic acid | Rattus norvegicus | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00021 | - |
IC50: 0.00021 mM | Rattus norvegicus | nordihydroguiaraetic acid | |
0.0012 | - |
IC50: 0.0012 mM | Rattus norvegicus | baicalein | |
0.0021 | - |
IC50: 0.0021 mM | Rattus norvegicus | quercetin | |
0.0026 | - |
IC50: 0.0026 mM | Rattus norvegicus | AA861 | |
0.0045 | - |
IC50: 0.0045 mM | Rattus norvegicus | esculetin | |
0.028 | - |
IC50: 0.028 mM | Rattus norvegicus | 5,8,11,13-eicosatetraynoic acid | |
0.033 | - |
IC50: 0.033 mM | Rattus norvegicus | rutin | |
0.046 | - |
IC50: 0.046 mM | Rattus norvegicus | caffeic acid | |
0.062 | - |
IC50: 0.062 mM | Rattus norvegicus | catechol | |
0.098 | - |
IC50: 0.098 mM | Rattus norvegicus | Cirsiliol | |
0.098 | - |
IC50: 0.098 mM | Rattus norvegicus | eupatilin | |
0.36 | - |
IC50: 0.36 mM | Rattus norvegicus | indomethacin | |
0.49 | - |
IC50: 0.49 mM | Rattus norvegicus | norepinephrine | |
0.53 | - |
IC50: 0.53 mM | Rattus norvegicus | BW755C | |
0.98 | - |
IC50: 0.98 mM | Rattus norvegicus | epinephrine |