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Literature summary for 1.13.11.34 extracted from

  • Furukawa, M.; Yoshimoto, T.; Ochi, K.; Yamamoto, S.
    Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells (1984), Biochim. Biophys. Acta, 795, 458-465.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ADP about half as active as ATP Rattus norvegicus
AMP about half as active as ATP Rattus norvegicus
ATP stimulates Rattus norvegicus
CTP about half as active as ATP Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 0.01 mM, 34% inhibition Rattus norvegicus
5,8,11,13-eicosatetraynoic acid IC50: 0.028 mM Rattus norvegicus
8-hydroxyquinoline 0.01 mM, 59% inhibition Rattus norvegicus
AA861 IC50: 0.0026 mM Rattus norvegicus
baicalein IC50: 0.0012 mM Rattus norvegicus
BW755C CAS: 66000-40-6; IC50: 0.53 MM Rattus norvegicus
caffeic acid IC50: 0.046 mM Rattus norvegicus
catechol IC50: 0.062 mM Rattus norvegicus
Cirsiliol IC50: 0.098 mM Rattus norvegicus
epinephrine IC50: 0.98 mM Rattus norvegicus
esculetin IC50: 0.0045 mM Rattus norvegicus
eupatilin IC50: 0.098 mM Rattus norvegicus
indomethacin IC50: 0.36 mM Rattus norvegicus
iodoacetamide 0.01 mM, 20% inhibition Rattus norvegicus
NEM 0.01 mM, 75% inhibition Rattus norvegicus
nordihydroguiaraetic acid IC50: 0.00021 mM Rattus norvegicus
norepinephrine IC50: 0.49 mM Rattus norvegicus
quercetin IC50: 0.0021 mM Rattus norvegicus
rutin IC50: 0.033 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
arachidonic acid
-
Rattus norvegicus
0.024
-
5,8,11,14,17-eicosapentaenoic acid
-
Rattus norvegicus
0.032
-
5,8,11-eicosatrienoic acid
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ 45% of the activation with Ca2+ Rattus norvegicus
Ca2+ required Rattus norvegicus
Ca2+ half-maximal activity at 0.1 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
4°C, 48 h, no appreciable loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,8,11,14,17-eicosapentaenoic acid + O2
-
Rattus norvegicus ?
-
?
5,8,11-eicosatrienoic acid + O2 almost as active as arachidonic acid Rattus norvegicus ?
-
?
8,11,14-eicosatrienoic acid + O2
-
Rattus norvegicus ?
-
?
arachidonate + O2 i.e. 5,8,11,14-eicosatetraenoic acid Rattus norvegicus (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00021
-
IC50: 0.00021 mM Rattus norvegicus nordihydroguiaraetic acid
0.0012
-
IC50: 0.0012 mM Rattus norvegicus baicalein
0.0021
-
IC50: 0.0021 mM Rattus norvegicus quercetin
0.0026
-
IC50: 0.0026 mM Rattus norvegicus AA861
0.0045
-
IC50: 0.0045 mM Rattus norvegicus esculetin
0.028
-
IC50: 0.028 mM Rattus norvegicus 5,8,11,13-eicosatetraynoic acid
0.033
-
IC50: 0.033 mM Rattus norvegicus rutin
0.046
-
IC50: 0.046 mM Rattus norvegicus caffeic acid
0.062
-
IC50: 0.062 mM Rattus norvegicus catechol
0.098
-
IC50: 0.098 mM Rattus norvegicus Cirsiliol
0.098
-
IC50: 0.098 mM Rattus norvegicus eupatilin
0.36
-
IC50: 0.36 mM Rattus norvegicus indomethacin
0.49
-
IC50: 0.49 mM Rattus norvegicus norepinephrine
0.53
-
IC50: 0.53 mM Rattus norvegicus BW755C
0.98
-
IC50: 0.98 mM Rattus norvegicus epinephrine