EC Number   |
Metals/Ions |
Reference |
|---|
    4.6.1.12 | Mn2+ |
Mg2+ or Mn2+, positioned between the alpha- and beta-phosphates of the substrate, acts in concert with the Zn2+ to align and polarize the substrate for catalysis |
709435 |
| 4.6.1.12 | Mn2+ |
Mn2+ or Mg2+ required |
657177 |
| 4.6.1.12 | Mn2+ |
preferred |
708124 |
| 4.6.1.12 | more |
the tetrahedrally arranged transition metal binding site, potentially occupied by Mn2+, sits at the base of the active site cleft. A phosphate oxygen of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate and the side chains of Asp8, His10, and His42 occupy the metal side chains of Asp8, His10, and His42 occupy the metal side coordination sphere |
656112 |
| 4.6.1.12 | Na+ |
presence of tetrahedral Zn2+ in one of the metal-binding sites and an octahedral sodium ion in the second metal site in absence of substrate |
654130 |
| 4.6.1.12 | Zinc |
tightly binds one zinc ion per subunit of the trimer at the active site, which helps to position the substrate for direct attack of the 2-phosphate group on the beta-phosphate |
656498 |
| 4.6.1.12 | Zn2+ |
- |
663548 |
| 4.6.1.12 | Zn2+ |
active site contains a Zn2+ with tetrahedral coordination |
657196 |
| 4.6.1.12 | Zn2+ |
active site including a Zn2+ ligand (Asp92-His94-His126) |
709487 |
| 4.6.1.12 | Zn2+ |
presence of tetrahedral Zn2+ in one of the metal-binding sites and an octahedral sodium ion in the second metal site in absence of substrate |
654130 |
