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EC Number
Inhibitors
Commentary
Structure
6.4.1.8
beta,gamma-Imido-ATP
2 mM, complete inhibition of acetophenone carboxylase activity, non-competitive inhibition
6.4.1.8
Carbamoyl phosphate
2 mM: 50% inhibition of ATPase activity. 8 mM: 50% inhibition of carboxylating activity
6.4.1.8
Mg2+
20 mM: 50% inhibition
6.4.1.8
Mn2+
10 mM: 50% inhibition
6.4.1.8
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acetophenone carboxylation activity in cell extracts is not sensitive to avidin, indicating that the enzyme is independent of biotin
6.4.1.8
Ni2+
1 mM: 50% inhibition of ATPase activity. 2.5 mM: 50% inhibition of carboxylation activity
6.4.1.8
Zn2+
the enzyme contains 1 Zn2+ ion per alphabetagammadelta core complex. In spite of the presence of Zn in the enzyme, it is strongly inhibited by Zn2+ ions. 0.2 mM ZnCl2: 50% inhibition of ATPase activity and carboxylation activity
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