Ligand carbamoyl phosphate

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Basic Ligand Information

Molecular Structure
Picture of carbamoyl phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH4NO5P
carbamoyl phosphate
FFQKYPRQEYGKAF-UHFFFAOYSA-N
Synonyms:
carbamoyl-phosphate, Carbamoylphosphate, carbamyl phosphate, Carbamylphosphate

Show all pahtways known for Show all pathways known for carbamoyl phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (75 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + decarbamoylnovobiocin = phosphate + novobiocin
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carbamoyl phosphate + oxamate = phosphate + oxalureate
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carbamoyl phosphate + a 3-hydroxymethyl ceph-3-em-4-carboxylate = phosphate + a 3-carbamoyloxymethylcephem
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ADP + carbamoyl phosphate = ATP + NH3 + CO2
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carbamoyl phosphate + H2O = carbamate + phosphate
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In Vivo Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + NH3 + CO2 = ADP + carbamoyl phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (145 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + oxamate = phosphate + oxalureate
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carbamoyl phosphate + L-lysine = phosphate + L-homocitrulline
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D-glucose + carbamoyl phosphate = D-glucose 6-phosphate + carbamate
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carbamoyl phosphate + inosine = carbamate + IMP
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ADP + carbamoyl phosphate = ATP + NH3 + CO2
show the reaction diagram
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carbamoyl phosphate + H2O = carbamate + phosphate
show the reaction diagram
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carbamoyl phosphate + H2O = carbamate + phosphate
show the reaction diagram
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ADP + carbamoyl phosphate = ATP + carbamate
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ATP + ribose 5-phosphate + carbamoylphosphate = ADP + phosphate + 5-phosphoribosylamine + formate
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Product in Enzyme-catalyzed Reactions (35 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-carbamoylputrescine + phosphate = putrescine + carbamoyl phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, activity is stimulated more than 10fold
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Inhibitor in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
3 mM, 25% loss of activity
-
competitive
-
erythrocyte enzyme, competitive inhibition, Ki: 6.9 mM
-
50% inhibition at 13 mM
-
2 mM: 50% inhibition of ATPase activity. 8 mM: 50% inhibition of carboxylating activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (26 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
82
-
pH 8.0, 37C
319
-
pH 7.5, 25C

KM Value (74 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0051
-
pH 8.5, 22C
11.9
-
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Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.018
-
-
6.9
-
erythrocyte enzyme, competitive inhibition
13
-
-

References & Links

Links to other databases for carbamoyl phosphate

ChEBI
PubChem
ChEBI
PubChem