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EC Number
Inhibitors
Commentary
Structure
3.2.2.17
2-[N-(acetoxyacetyl)amino]fluorene
AAAF, carcinogen , extensive modification of DNA does not significantly reduce the thymine dimer yield
3.2.2.17
DNA
depurinated DNA competitively inhibits the UV endonuclease activity, irradiated DNA inhibits the AP endonuclease activity
3.2.2.17
NaBH4
-
3.2.2.17
NaBH4
The rate of the covalent imine intermediate suggest that the reduction of the intermediate is rate-limiting in the reaction
3.2.2.17
NaBH4
reduces the imino intermediate resulting in a stable covalent linkage between the enzyme and the DNA
3.2.2.17
NaCl
nicking activity rather inhibited
3.2.2.17
NaCl
above 40 mM
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