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16-mers oligodeoxynucleotide + H2O
?
-
anomers of methyl-deoxyribofuranose analogues indicates that T4-pdg preferentially cleaved the beta-anomers
-
-
?
DNA phiX174 RFI + H2O
thymine + ?
oligonucleotides + H2O
dCMP + dTMP
poly(dAdT) + H2O
oligonucleotides
Tequatrovirus T4
-
-
acid-soluble oligonucleotides, length less than 15 nucleotides
?
additional information
?
-
DNA + H2O
?
-
the combined rate of sugar ring opening and reduction of the sugar is significantly slower than the rate of formation of (T4-pdg)-DNA intermediate
-
-
?
DNA + H2O
?
-
pyrimidine cyclobutane dimer formed between adjacent pyrimidines
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
-
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
UV-irradiated DNA, containing thymine dimers
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
removal of UV-induced pyrimidine dimer photoproducts
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
the enzyme incises DNA at cyclobutane pyrimidine dimers that are formed as a consequence of exposure to ultraviolet light. The investigation reveals a temporal uncoupling of the T4-Pdg-induced DNA bending and nucleotide flipping
-
-
?
DNA + H2O
thymine + ?
-
-
-
-
?
DNA + H2O
thymine + ?
-
-
-
-
?
DNA + H2O
thymine + ?
-
enzyme mechanism glycosylase/AP lyase, cis-syn and trans-synII-isomers of cyclobutane pyrimidine dimers in double-stranded DNA
-
-
?
DNA + H2O
thymine + ?
-
cis-syn pyrimidine dimer specific
-
-
?
DNA + H2O
thymine + ?
Tequatrovirus T4
-
-
-
-
?
DNA + H2O
thymine + ?
Tequatrovirus T4
-
beta-elimination reaction results in an alpha,beta-unsaturated aldehyde
-
-
?
DNA + H2O
thymine + ?
Tequatrovirus T4
-
strict specificity for DNA cyclobutyldipyrimidines
-
-
?
DNA + H2O
thymine + ?
Tequatrovirus T4
-
double stranded DNA containing pyrimidine dimers
-
-
?
DNA + H2O
thymine + ?
Tequatrovirus T4
-
UV-irradiated DNA, containing thymine dimers
enzymatic photoreactivation, direct photoreversal, releases free thymine from E. coli DNA
?
DNA phiX174 RFI + H2O
thymine + ?
-
irradiated with increasing doses of UV light
-
-
?
DNA phiX174 RFI + H2O
thymine + ?
-
double-stranded covalently closed circular DNA molecule contains apurinic sites
-
?
oligonucleotide + H2O
?
-
49-mers containing a single site-specific cis-syn, trans-syn I or trans-syn II thymine dimer
beta elimination reaction results in products wich have 3'4-hydroxy-2-pentanal ends
-
?
oligonucleotide + H2O
?
-
49-mers radiolabeled containing a site-specific uracil with uracil DNA glycosylase
incise of AP sites resulting in beta- and delta-elimination products with 3'4-hydroxy-2-pentenal and 3'-phosphate termini respectively
-
?
oligonucleotide + H2O
?
-
containing either a (6-4) or Dewar photoproduct of TpT
-
-
?
oligonucleotides + H2O
dCMP + dTMP
-
-
-
?
oligonucleotides + H2O
dCMP + dTMP
-
49mers containing a site specific cis-syn, trans-syn I or trans-syn II thymine dimer, beta-elimination reaction
-
-
?
additional information
?
-
-
unable to incise DNA containing either A:G, A:8-oxoG or 8-oxoG:C mismatches
-
-
?
additional information
?
-
-
3'nicking is not result of the hydrolysis of the phospho ester bond, but rather result of a beta-elimination reaction, the sequence of the 138 amino acid residues of T4 UV endonuclease is known, active sites for DNA glycosylase and the nicking activity seem to be independent, since endonuclease is a phosphoric diester hydrolase classified as EC 3.1.4.-T4 UV endonuclease and Micrococcus luteus endonuclease are not endonucleases
-
-
?
additional information
?
-
-
UV-specific endonuclease inactive on UV single-stranded DNA, N-glycosylase activity less active on single-stranded substrate
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
3'nicking is not result of the hydrolysis of the phospho ester bond, but rather result of a beta-elimination reaction, the sequence of the 138 amino acid residues of T4 UV endonuclease is known, active sites for DNA glycosylase and the nicking activity seem to be independent, since endonuclease is a phosphoric diester hydrolase classified as EC 3.1.4.-T4 UV endonuclease and Micrococcus luteus endonuclease are not endonucleases
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
the enzyme reduces the incidence of basal-cell and squamous cell carcinoma in mice. Treatment of Cdk4(R24C/R24C)/Nras(Q61K) mice topically with the T4 endonuclease V DNA repair enzyme immediately prior to neonatal ultraviolet radiation (UVR) exposure has a powerful effect in exacerbating melanoma development, overview
-
-
?
additional information
?
-
Tequatrovirus T4 T4denV+
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
?
-
DNA + H2O
?
-
pyrimidine cyclobutane dimer formed between adjacent pyrimidines
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
UV-irradiated DNA, containing thymine dimers
-
-
?
DNA + H2O
?
Tequatrovirus T4
-
removal of UV-induced pyrimidine dimer photoproducts
-
-
?
additional information
?
-
-
UV-specific endonuclease inactive on UV single-stranded DNA, N-glycosylase activity less active on single-stranded substrate
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
additional information
?
-
Tequatrovirus T4
-
the enzyme reduces the incidence of basal-cell and squamous cell carcinoma in mice. Treatment of Cdk4(R24C/R24C)/Nras(Q61K) mice topically with the T4 endonuclease V DNA repair enzyme immediately prior to neonatal ultraviolet radiation (UVR) exposure has a powerful effect in exacerbating melanoma development, overview
-
-
?
additional information
?
-
Tequatrovirus T4 T4denV+
-
only nicking of UV-irradiated DNA, creating phospho diester bond breaks 5' with respect to pyrimidine dimers, protein containing the glycosylase activity also contains the apyrimidinic endonuclease activity, multifunctional enzyme, 2 distinct domains in a single enzyme molecule possess both pyrimidine dimer-DNA glycosylase, and AP endonuclease activity, first the glycosylase cleaves glycosylic bond of one of the pyrimidine residues of a dimer to yield an AP site, then AP endonuclease hydrolyzes the phospho diester bond near the AP site, prefers duplex DNA to single-stranded
-
-
?
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Nakabeppu, Y.; Yamashita, K.; Sekiguchi, M.
Purification and characterization of normal and mutant forms of T4 endonuclease V
J. Biol. Chem.
257
2556-2562
1982
Tequatrovirus T4
brenda
Recinos , A.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: role of lysine-130
Biochemistry
27
1832-1838
1988
Tequatrovirus T4
brenda
Stump, D.G.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: role of tyrosine-129 and -131 in pyrimidine dimer-specific binding
Biochemistry
27
1839-1843
1988
Tequatrovirus T4
brenda
Ishida, M.; Kanamori, Y.; Hori, N.; Inaoka, T.; Ohtsuka, E.
In vitro and in vivo activities of T4 endonuclease V mutants altered in the C-terminal aromatic region
Biochemistry
29
3817-3821
1990
Tequatrovirus T4
brenda
Nakabeppu, Y.; Sekiguchi, M.
Physical association of pyrimidine dimer DNA glycosylase and apurinic/apyrimidinic DNA endonuclease essential for repair of ultraviolet-damaged DNA
Proc. Natl. Acad. Sci. USA
78
2742-2746
1981
Tequatrovirus T4
brenda
Radany, E.H.; Friedberg, E.C.
A pyrimidine dimer-DNA glycosylase activity associated with the v gene product of bacteriophage T4
Nature
286
183-185
1980
Tequatrovirus T4
-
brenda
Haseltine, W.A.; Gordon, L.K.; Lindan, C.P.; Grafstrom, R.H.; Shaper, N.L.; Gropssmann, L.
Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus
Nature
285
634-641
1980
Micrococcus luteus
brenda
Warner, H.R.; Christensen, L.M.; Persson, M.L.
Evidence that the UV endonuclease activity induced by bacteriophage T4 contains both pyrimidine dimer-DNA glycosylase and apyrimidinic/apurinic endonuclease activities in the enzyme molecule
J. Virol.
10
204-210
1981
Tequatrovirus T4, Micrococcus luteus
-
brenda
McMillan, S.; Edenberg, H.J.; Radany, E.H.; Friedberg, R.C.; Friedberg, E.C.
denV gene of bacteriophage T4 codes for both pyrimidine dimer-DNA glycosylase and apyrimidinic endonuclease activities
J. Virol.
40
211-223
1981
Tequatrovirus T4, Tequatrovirus T4 T4denV+
brenda
Radany, E.H.; Friedberg, E.C.
Demonstration of pyrimidine dimer-DNA glycosylase activity in vivo: bacteriophage T4-infected Escherichia coli as a model system
J. Virol.
41
88-96
1982
Tequatrovirus T4
brenda
Gordon, L.K.; Haseltine, W.A.
Comparison of the cleavage of pyrimidine dimers by the bacteriophage T4 and Micrococcus luteus UV-specific endonucleases
J. Biol. Chem.
255
12047-12050
1980
Micrococcus luteus
brenda
Seawell, P.C.; Smith, C.A.; Ganesan, A.K.
DenV gene of bacteriophage T4 determines a DNA glycosylase specific for pyrimidine dimers in DNA
J. Virol.
35
790-797
1980
Tequatrovirus T4, Tequatrovirus T4 T4denV1
brenda
Bailly, V.; Sente, B.; Verly, W.G.
Bacteriophage-T4 and Micrococcus luteus UV endonucleases are not endonucleases but beta-elimination and sometimes betadelta-elimination catalysts
Biochem. J.
259
751-759
1989
Tequatrovirus T4, Micrococcus luteus
brenda
Duker, N.J.; Merkel, G.W.
Inhibition of enzymic incision of thymine dimers by covalently bound 2-[N-[(Deoxyguanosin-8-yl)acetyl]amino]fluorene in deoxyribonucleic acid
Biochemistry
24
408-412
1985
Tequatrovirus T4
brenda
Doi, T.; Recktenwald, A.; Karaki, Y.; Kikuchi, M.; Morikawa, K.; Ikehara, M.; Inaoka, T.; Hori, N.; Ohtsuka, E.
Role of the basic amino acid cluster and Glu-23 in pyrimidine dimer glycosylase activity of T4 endonuclease V
Proc. Natl. Acad. Sci. USA
89
9420-9424
1992
Tequatrovirus T4
brenda
Nyaga, S.G.; Dodson, M.L.; Lloyd, R.S.
Role of specific amino acid residues in T4 endonuclease V that alter nontarget DNA binding
Biochemistry
36
4080-4088
1997
Tequatrovirus T4
brenda
McCullough, A.K.; Romberg, M.T.; Nyaga, S.; Wie, Y.; Wood, T.G.; Taylor, J.S.; Van Etten, J.L.; Dodson, M.L.; Lloyd, R.S.
Characterization of a novel cis-syn and trans-symII pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus Paramecium bursaria chlorella Virus-1
J. Biol. Chem.
273
13136-13142
1998
Tequatrovirus T4, Micrococcus luteus, Paramecium bursaria Chlorella virus 1
brenda
Garvish, J.F.; Lloyd, R.S.
The catalytic mechanism of a pyrimidine dimer-specific glycosylase(pdg)/abasic lyase, Chlorella virus-pdg
J. Biol. Chem.
274
9786-9794
1999
Tequatrovirus T4, Paramecium bursaria Chlorella virus 1
brenda
Garvish, J.F.; Lloyd, R.S.
Active-site determination of a pyrimidine dimer glycosylase
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2000
Paramecium bursaria Chlorella virus 1
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Sun, L.; Li, Y.; McCullough, A.K.; Wood, T.G.; Lloyd, R.S.; Adams, B.; Gurnon, J.R.; Van Etten, J.L.
Intron conservation in a UV-specific DNA repair gene encoded by Chlorella viruses
J. Mol. Evol.
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2000
Tequatrovirus T4, Paramecium bursaria Chlorella virus 1
brenda
Green, A.P.; deRiel, J.K.; Henderson, E.E.
Structure/function analysis of the Ala116-Lys121 region of endonuclease V by random targeted mutagenesis
Nucleic Acids Res.
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1993
Tequatrovirus T4
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Grafstrom, R.H.; Park, L.; Grossman, L.
Enzymatic repair of pyrimidine dimer-containing DNA. A 5' dimer DNA glycosylase: 3'-apyrimidinic endonuclease mechanism from Micrococcus luteus
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Micrococcus luteus
brenda
McCullough, A.K.; Sanchez, A.; Dodson, M.L.; Marapaka, P.; Taylor, J.S.; Lloyd, R.S.
The reaction mechanism of DNA glycosylase/AP lyases at abasic sites
Biochemistry
40
561-568
2001
Escherichia coli
brenda
Meador, M.G.; Rajagopalan, L.; Lloyd, R.S.; Dodson, M.L.
Role of His-16 in turnover of T4 pyrimidine dimer glycosylase
J. Biol. Chem.
279
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2004
Tequatrovirus T4, Escherichia coli
brenda
Vasquez, D.A.; Nyaga, S.G.; Lloyd, R.S.
Purification and characterization of a novel UV lesion-specific DNA glycosylase/AP lyase from Bacillus sphaericus
Mutat. Res.
459
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2000
Lysinibacillus sphaericus
brenda
Jaruga, P.; Jabil, R.; McCullough, A.K.; Rodriguez, H.; Dizdaroglu, M.; Lloyd, R.S.
Chlorella virus pyrimidine dimer glycosylase excises ultraviolet radiation- and hydroxyl radical-induced products 4,6-diamino-5-formamidopyrimidine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from DNA
Photochem. Photobiol.
75
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2002
Paramecium bursaria Chlorella virus 1
brenda
Walker, R.K.; McCullough, A.K.; Lloyd, R.S.
Uncoupling of nucleotide flipping and DNA bending by the T4 pyrimidine dimer DNA glycosylase
Biochemistry
45
14192-14200
2006
Tequatrovirus T4
brenda
Emanuel, P.; Scheinfeld, N.
A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidants
Dermatol. Online J.
13(3)
10
2007
Tequatrovirus T4
brenda
Kang, C.S.; Son, S.; Bang, I.S.
High-level expression of T4 endonuclease V in insect cells as biologically active form
J. Microbiol. Biotechnol.
16
1583-1590
2006
Tequatrovirus T4
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brenda
Golan, G.; Zharkov, D.O.; Grollman, A.P.; Dodson, M.L.; McCullough, A.K.; Lloyd, R.S.; Shoham, G.
Structure of T4 pyrimidine dimer glycosylase in a reduced imine covalent complex with abasic site-containing DNA
J. Mol. Biol.
362
241-258
2006
Tequatrovirus T4
brenda
Chelico, L.; Haughian, J.L.; Woytowich, A.E.; Khachatourians, G.G.
Quantification of ultraviolet-C irradiation induced cyclobutane pyrimidine dimers and their removal in Beauveria bassiana conidiospore DNA
Mycologia
97
621-627
2006
Tequatrovirus T4
brenda
Bennett, S.E.; Kitner, J.
Characterization of the aldehyde reactive probe reaction with AP-sites in DNA: influence of AP-lyase on adduct stability
Nucleosides Nucleotides Nucleic Acids
25
823-842
2006
Tequatrovirus T4
brenda
Jiang, L.; Wang, Y.; Li, S.
Application of the comet assay to measure DNA damage induced by UV radiation in the hydrophyte, Spirodela polyrhiza
Physiol. Plant.
129
652-657
2007
Tequatrovirus T4
brenda
Hacker, E.; Muller, H.K.; Hayward, N.; Fahey, P.; Walker, G.
Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4(R24C/R24C)/Tyr-Nras(Q61K) mice following neonatal UVR
Pigment Cell Melanoma Res.
23
121-128
2010
Tequatrovirus T4
brenda
Dodson, M.L.; Walker, R.C.; Lloyd, R.S.
Carbinolamine formation and dehydration in a DNA repair enzyme active site
PLoS ONE
7
e31377
2012
Tequatrovirus T4 (P04418)
brenda