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EC Number
Inhibitors
Commentary
Structure
2.4.2.7
2,6-diaminopurine
competitive
2.4.2.7
4-aminopteridine
-
2.4.2.7
4-aminopyrido(2,3-d)pyrimidine
-
2.4.2.7
4-aminopyrolo(2,3-d)pyrimidine
-
2.4.2.7
6-Mercaptopurine
competitive
2.4.2.7
adenine
-
2.4.2.7
adenine
at high concentrations, at low 5-phospho-alpha-D-ribose 1-diphosphate concentration
2.4.2.7
adenine
substrate inhibition, 0.08 mM, 50% inhibition in Propositus (HPRT-) and 20% in control(HPRT+)
2.4.2.7
ADP
-
2.4.2.7
ADP
is a much stronger inhibitor than ATP at pH 4.5, but has virtually no effect on activity at neutral pH
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