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Information on EC 2.4.2.7 - adenine phosphoribosyltransferase
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EC Tree
2.4.2.7 adenine phosphoribosyltransferaseIUBMB Comments
5-Amino-4-imidazolecarboxamide can replace adenine.
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Word Map
- 2.4.2.7
- purine
- hamster
- hypoxanthine
-
salvage
-
2,8-dihydroxyadenine
- ovary
- erythrocyte
-
hypoxanthine-guanine
- nucleoside
- stone
- guanine
- urolithiasis
- allopurinol
- deaminase
- xanthine
- hgprt
-
heterozygosity
- inosine
-
uric
- lesch-nyhan
- nephrolithiasis
-
hemizygous
- 2,6-diaminopurine
- phosphoribosyltransferases
- imp
-
5-phosphoribosyl-1-pyrophosphate
- gout
-
radiolucent
- calculi
-
transversions
-
crystalluria
-
hprt-deficient
-
repair-deficient
- lithiasis
- hgprtase
- synthesis
- drug development
-
hemolysates
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3.5.4.4
-
repair-proficient
-
2.7.1.20
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
aprt, adenine phosphoribosyltransferase, adenine phosphoribosyl transferase, aprtase, gpt-1, adenosine phosphoribosyltransferase, amp pyrophosphorylase, haprt, aprt1, aprth, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
adenine phosphoribosyl transferase
adenine phosphoribosylpyrophosphate transferase
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-
-
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adenine phosphoribosyltransferase
adenine phosphoribosyltransferase 2
adenione PRTase
adenosine phosphoribosyltransferase
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-
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adenylate pyrophosphorylase
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-
-
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adenylic pyrophosphorylase
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-
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AMP pyrophosphorylase
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-
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AMP-pyrophosphate phosphoribosyltransferase
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-
-
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AMP:pyrophosphate phospho-D-ribosyltransferase
APRT
APRT1
APRT2
APRTase
APRTh
apT
FtAPRT
gpT-1
phosphoribosyltransferase, adenine
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-
-
-
ScAPRT
SSO2342
transphosphoribosidase
-
-
-
-
TtAPRT2
TTC1249
TTC1250
TTH1250
TTHA1614
TthAPRT
TthHB27APRT
TT_C1249
TT_C1250
type I PRT
additional information
structure analysis: different paths for adenine relative to other purine PRTases
AMP:pyrophosphate phospho-D-ribosyltransferase
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-
-
-
APRT
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
mechanism
-
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
mechanism
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
ping-pong mechanism
-
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
catalytic site: amino acid residues 106-108
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AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
forward reaction follows a random bi-bi mechanism
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
-
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
active site structure
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
ordered bi-bi mechanism, kinetics
-
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
molecular reaction mechanism in both directions of the reaction for hAPRT: in the forward reaction, SN2-type molecular mechanism including some SN1 characteristics, and in the reverse reaction, a proposed magnesium-assisted SN2-type mechanism, detailed overview
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
the enzyme with reversible activities has an ordered sequential bibi reaction mechanism
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pentosyl group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
AMP:diphosphate phospho-D-ribosyltransferase
5-Amino-4-imidazolecarboxamide can replace adenine.
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CAS REGISTRY NUMBER
COMMENTARY
9027-80-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
2-aminobenzimidazole 5'-phosphoribosyl nucleotide + diphosphate
2-aminobenzimidazole + 5-phospho-alpha-D-ribose 1-diphosphate
very low activity
-
-
r
2-chloro-AMP + diphosphate
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
best substrate
-
-
r
2-fluoro-AMP + diphosphate
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
2-methoxyadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-methoxyadenosine 5'-monophosphate + diphosphate
-
-
-
r
2-methoxyadenosine 5'-phosphate + diphosphate
2-methoxyadenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
4-amino-5-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
4-amino-5-imidazolecarboxamide ribotide + diphosphate
-
-
-
-
?
4-aminopyrazolo-(3,4-d)-pyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate
4-aminopyrazolo-(3,4-d)-pyrimidine ribotide + diphosphate
-
-
-
-
?
4-carbamoylimidazolium 5-olate + 5-phospho-alpha-D-ribose 1-diphosphate
4-carbamoylimidazolium 5-olate 5'-phosphate + diphosphate
-
low activity
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
6-amino-2-hydroxypurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-amino-2-hydroxypurine ribotide + diphosphate
-
-
-
-
?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine ribotide + diphosphate
-
-
-
-
?
6-methoxyguanine + 5-phospho-alpha-D-ribose 1-diphosphate
6-methoxyguanosine 5'-monophosphate + diphosphate
-
-
-
r
6-methylpurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-methylpurine ribonucleoside-5'-monophosphate + diphosphate
-
-
-
r
6-methylpurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-methylpurine ribotide + diphosphate
-
-
-
-
?
8-azaadenine + 5-phospho-alpha-D-ribose 1-diphosphate
8-azaadenosine 5'-phosphate + diphosphate
-
-
-
-
?
benzyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
benzyladenosine 5'-phosphate + diphosphate
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
-
at about 5.7% of the conversion rate for adenine
-
-
?
isopentenyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
isopentenyladenosine 5'-phosphate + diphosphate
N1-methoxyadenine + 5-phospho-alpha-D-ribose 1-diphosphate
N1-methoxyadenosine 5'-monophosphate + diphosphate
-
-
-
r
N1-methyladenosine 5'-phosphate + diphosphate
N1-methyladenosine + 5-phospho-alpha-D-ribose 1-diphosphate
high activity
-
-
r
N6-benzyladenosine 5'-phosphate + diphosphate
N6-benzyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
very low activity
-
-
r
N6-furfuryladenine + 5-phospho-alpha-D-ribose 1-diphosphate
N6-furfuryladenosine 5'-phosphate + diphosphate
-
-
-
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
xanthosine 5'-phosphate + diphosphate
-
-
-
-
?
zeatin + 5-phospho-alpha-D-ribose 1-diphosphate
zeatin riboside 5'-phosphate + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
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-
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r
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
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-
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r
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
-
-
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r
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
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specific for adenine or 2,6-diaminopurine
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-
?
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
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-
-
-
?
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
-
-
-
-
?
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
low activity
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-
r
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
-
-
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r
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
-
-
-
r
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
-
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
no activity
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
enzyme deficiency leads to severe renal failure, overview
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-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
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-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
the enzyme is involved in the salvage of adenosine, overview
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
the enzyme is involved in the salvage of adenosine, overview
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
the enzyme is involved in the salvage of adenosine, overview
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
best acceptor substrate
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
isoform APT1 shows 100% activity with adenine
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
equilibrium lies far in the direction of nucleotide synthesis
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
adenine salvage enzyme
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
specific for adenine or 2,6-diamino-purine
5'-AMP
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
enzyme mediates the translocation of adenine into the cell as AMP
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
necessary for appropriate regulation of purine de novo biosynthesis
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
ordered substrate binding in the reverse reaction with AMP bound first followed by diphosphate
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
substrate binding structure
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
best acceptor substrate
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
highly specific for the donor substrate
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
human APRT deficiency results in serious kidney illness such as nephrolithiasis, interstitial nephritis, and chronic renal failure as a result of 2,8-dihydroxyadenine precipitation in the renal interstitium
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
binding to hAPRT is substrate shape-specific in the forward reaction, whereas it is base-specific in the reverse reaction
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
human APRT catalyzes the transformation of adenine into AMP and vice versa
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
substrate binding structure
AMP is bound in the low energy anti conformation with the ribose in the 2' endo conformation
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
strong preference for adenine as substrate over the 6-oxopurine bases, hypoxanthine and guanine
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
strong preference for adenine as substrate over the 6-oxopurine bases, hypoxanthine and guanine
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
diphosphate does not bind at the active site, but near the N-terminal side at Arg69
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?