Ligand 2,6-diaminopurine

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Basic Ligand Information

Molecular Structure
Picture of 2,6-diaminopurine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6N6
2,6-diaminopurine
MSSXOMSJDRHRMC-UHFFFAOYSA-N
Synonyms:
2-aminoadenine, 7H-purine-2,6-diamine, diaminopurine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,6-diaminopurine + NAD+ + H2O = ? + NADH + H+
show the reaction diagram
-
2,6-diaminopurine + H2O + O2 = 2,6-diamino-7,9-dihydro-8H-purin-8-one
show the reaction diagram
-
2,6-diaminopurine + alpha-D-ribose 1-phosphate = 2,6-diaminopurine ribonucleoside + phosphate
show the reaction diagram
-
guanosine + 2,6-diaminopurine = guanine + 2,6-diaminopurine ribonucleoside
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate = 2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
-
-
2,6-diamino-9-beta-D-ribofuranosylpurine + H2O = 2,6-diaminopurine + D-ribose
show the reaction diagram
-
-
2-aminoAMP + H2O = 2-aminoadenine + D-ribose 5-phosphate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
poor inhibitor
-
competitive
-
10 mM, 29.3% inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.89
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1
-
-
0.00188
-
in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25C

References & Links

Links to other databases for 2,6-diaminopurine

ChEBI
PubChem
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PubChem