EC Number   |
Inhibitors |
Structure  |
|---|
    1.13.11.33 | more |
the enzyme undergoes suicidal inactivation, during fatty acid oxygenation |
 |
| 1.13.11.33 | more |
IC50 above 0.1 mM: compound 1a, compound 1b, compound 1d, compound 1e, compound 1g |
|
| 1.13.11.33 | more |
docking experiments and qualitative structure-activity relationship, QSAR, data, overview |
|
| 1.13.11.33 | more |
development of an assay method for high throughput screening of libraries for platelet-type 12-hLO selective inhibitors, four organo-mercurial compounds with NCI library IDs NSC20410, NSC268879, NSC321237, and NSC321239, are also found to be selectively inhibitory, but not pursued further due to their potentially toxic side effects, overview |
|
| 1.13.11.33 | more |
comparison of structural requirements for flavonoid inhibitory potency and selectivity against platelet 12-hLO, EC 1.13.11.31, and reticulocyte 15-hLO-1 and prostate epithelial 15-hLO-2, overview, catechols are essential for high potency, isoflavones and isoflavanones tend to select against 12-hLO, isoflavans tend to select against isozyme 15-hLO-1, but few flavonoids target isozyme 15-hLO-2, molecular modeling analysis, overview |
|
| 1.13.11.33 | more |
no inhibition by 2,6-dihydroxybenzoic acid |
|
| 1.13.11.33 | more |
quantitative structure activity relationship analysis using crystal structure, PDB ID 1IK3, EC 1.13.11.12, of the enzyme in complex with 13(S)-hydroperoxy-9(Z)-2,11(E)-octadecadienoic acid, docking studies, inhibitor binding structures, overview |
|
| 1.13.11.33 | more |
docking studies, inhibitor binding structures, overview |
|
| 1.13.11.33 | more |
synthesis and evaluation of 2,4,5-tri-substituted imidazoles, which show highly potent inhibition of 15-lipoxygenase with excellent selectivity over the lipoxygenases 5-LO, EC 1.13.11.34, and platelet 12-LO, EC 1.13.11.31 |
|
| 1.13.11.33 | more |
sulproston, misoprostol, and ONO-AE-248 inhibit acetylsalicylic acid-induced 15(S)-HETE production |
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