EC Number   |
Inhibitors |
Structure  |
|---|
    1.12.1.2 | more |
not inhibited by O2, CO and chelating agents |
 |
| 1.12.1.2 | more |
no inhibition by O2 |
|
| 1.12.1.2 | more |
release of one FMN reduces the NAD+ reduction by 90%, but is reversible by addition of excess FMN, insensitivity towards oxygen, with all 4 CN- groups bound to the enzyme, and towards CO |
|
| 1.12.1.2 | more |
when light adapted cells are transferred to darkness the expression of hoxE and hoxF is only slightly affected, while the transcript levels of hoxU, hoxY and hoxH are significantly (3-5fold) decreased. Putative regulators of hox gene expression sll0359 is suppressed in dark to a similar extent as hoxU, hoxY and hoxH. The transcriptional regulator lexA shows the opposite expression pattern than that of the hox genes, since it decreases in the light. When cells in microaerobic conditions are transferred to darkness the transcript levels of hoxU, hoxY, hoxH transcripts slightly decrease |
|
| 1.12.1.2 | NAD+ |
product inhibition; product inhibition |
  |
| 1.12.1.2 | NADH |
product inhibition; product inhibition |
|
| 1.12.1.2 | O2 |
slight inhibition of NAD+ reduction and H2 evolution from NADH |
|
| 1.12.1.2 | O2 |
irreversible enzyme inhibition by oxygen occurs if the CN- bound to Ni2+ is irreversibly removed or if the enzyme is reduced by NADH |
|
| 1.12.1.2 | O2 |
incubation of subunits HoxHY with O2 at high potentials causes slow inactivation, but activity is recovered within seconds at potentials below -170 mV at 30°C, even in the presence of 2% O2; incubation of subunits HoxHY with O2 at high potentials causes slow inactivation, but activity is recovered within seconds at potentials below -170 mV at 30°C, even in the presence of 2% O2 |
|
| 1.12.1.2 | Ni2+ |
0.5-1 mM, strong inhibition of artificial electron acceptor reduction |
|
