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EC Number
Inhibitors
Commentary
Structure
3.4.21.41
Ca2+
reaction with C1s
3.4.21.41
calreticulin
prevents C1 formation
3.4.21.41
dichloroisocoumarin
-
3.4.21.41
diisopropyl fluorophosphate
-
3.4.21.41
leupeptin
competitive
3.4.21.41
more
specific c-Jun amino-terminal kinase inhibitor and the MEK-1 inhibitor PD98059 do not regulate C1r mRNA expression, whereas JSH-23, which inhibits nuclear translocation of NF-kappaB decreases C1r expression selectively in MEF-2 cells
3.4.21.41
more
above 0.0005 mM C1rbar the enzyme aggregates with loss of activity
3.4.21.41
more
high ionic strength inhibits
3.4.21.41
NaCl
above 200 mM
3.4.21.41
p-amidinophenylmethylsulfonyl fluoride
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