3.4.21.41	3-alkoxy-4-chloro-7-guanidinoisocoumarin	-	46962	
3.4.21.41	4-chloro-3-(3-isothiureidopropoxy)isocoumarin	-	99870	
3.4.21.41	4-Nitrophenyl-4-guanidinobenzoate	-	20021	
3.4.21.41	C1 inhibitor	during complex formation, C1 inhibitor dissociates C1r and C1s from the activated C1 macromolecule, a process that is determined primarily by the interaction with C1r	4605	
3.4.21.41	C1 inhibitor	-	4605	
3.4.21.41	C1-inhibitor	regulates the classical and the lectin complement pathway inhibiting complement components C1r and C1s, and MASP-2, factor XIa, Factor XIIa, and plasma kallikrein, mechanism, overview	3691	
3.4.21.41	C1bar-inhibitor	Ca2+ decreases the rate at which C1rbar complexes with C1bar-inhibitor. C1rbar-(C1bar-inhibitor) interaction is accelerated by heparin. Flufenamic acid inhibits the action of the inhibitor	31428	
3.4.21.41	C1bar-inhibitor	irreversible	31428	
3.4.21.41	C1bar-inhibitor	kinetics of the reaction between inhibitor and enzyme	31428	
3.4.21.41	C1INH	sole inhibitor of the activated proteases C1r and C1s. Hereditary angioedema results from functional deficiency of the C1 inhibitor (C1INH) protein, which plays a key role in the classical pathway of complement activation	151533	
3.4.21.41	Ca2+	reaction with C1s	15	
3.4.21.41	calreticulin	prevents C1 formation	11459	
3.4.21.41	dichloroisocoumarin	-	9429	
3.4.21.41	diisopropyl fluorophosphate	-	244	
3.4.21.41	leupeptin	competitive	217	
3.4.21.41	additional information	specific c-Jun amino-terminal kinase inhibitor and the MEK-1 inhibitor PD98059 do not regulate C1r mRNA expression, whereas JSH-23, which inhibits nuclear translocation of NF-kappaB decreases C1r expression selectively in MEF-2 cells	2	
3.4.21.41	additional information	above 0.0005 mM C1rbar the enzyme aggregates with loss of activity	2	
3.4.21.41	additional information	high ionic strength inhibits	2	
3.4.21.41	NaCl	above 200 mM	42	
3.4.21.41	p-amidinophenylmethylsulfonyl fluoride	-	101231	
3.4.21.41	p-tosyl-Lys-chloromethyl ketone	-	101265	
3.4.21.41	phenylmethylsulfonyl fluoride	-	257	
3.4.21.41	polyanethol sulfonate	-	101329