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EC Number
Activating Compound
Commentary
Reference
3.4.21.B1
chondroitin sulfate
increases kininogen cleavage at above 1 mg/ml
650470
3.4.21.B1
Dextran sulfate
enhances autofragmentation and serine protease activity
650490
3.4.21.B1
Dextran sulfate
strongly accelerates autoactivation, strongest acceleration at 0.02 mg/ml of 5-kDa-dextran sulfate
650444
3.4.21.B1
heparan sulfate
-
687108
3.4.21.B1
heparan sulfate
increases kininogen cleavage at at 0.5-2 mg/ml
650470
3.4.21.B1
heparin
-
684975
,
687108
,
687578
3.4.21.B1
heparin
activates single-chain inactivate zymogen to the two-chain active enzyme
690121
3.4.21.B1
heparin
enhances autoactivation
651102
3.4.21.B1
heparin
increases kininogen cleavage at at 5-47 U/ml
650470
3.4.21.B1
heparin
strongly accelerates autoactivation, optimum concentration: 5-10 U/ml, presence of 7.5 U/ml reduces the half-life of the proenzyme from 12 min to 3.5 min
650444
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