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Literature summary for 3.4.21.B1 extracted from
- The hyaluronic acid-binding protease: a novel vascular and inflammatory mediator? (2008), Int. Immunopharmacol., 8, 166-170.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparan sulfate | - |
Homo sapiens |  |
| heparin | - |
Homo sapiens | |
| IL-8 | can stimulate the expression of HABP mRNA in lung microvascular endothelial cells and in bronchial epithelial cells | Homo sapiens | |
| poly-L-lysine | faciliates autocatalytic activation | Homo sapiens | |
| RNA | faciliates autocatalytic activation | Homo sapiens | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | plays a role in physiologic function of the pericellular environment of the vasculature. Proteolytically inactivates growth factors. May regulate angiogenic processes, like neovascularisation during tissue remodelling, wound repair or tumor progression. May contribute to extravascular fibrin deposition and inflammatory processes in the injured lung | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HUVEC cells. Subcutaneous systemic administration of SCID mice | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G511E | Marburg I mutant, underlies a polymorphism in the HABP2 gene, is found in 5-10% of the population. Is associated with an impaired pro-urikinase activation, and increased neointima formation correlated with reduced proteolysis of platlet derived growth factor-BB. The polymorphism is correlated with carotid stenosis and may contribute to the risk of venous thrombosis | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| artery | abundant in neointima and in arteriosclerotic carotid arteries, but not in normal arteries. Accumulation in unstable coronary atherosclerotic plaques with elevated RNA expression in patients with acute coronary syndromes | Homo sapiens | - |
| blood | circulation of HABP as a zymogen | Homo sapiens | - |
| liver | synthesis of HABP | Homo sapiens | - |
| lung | IL-8 can stimulate the expression of HABP mRNA in lung microvascular endothelial cells and in bronchial epithelial cells | Homo sapiens | - |
| plasma | elevated protein and activity levels of HABP in the plasma and in the broncheoalveolar fluid of patients with acquired respiratory distress syndrome | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| basic fibroblast growth factor + H2O | - |
Homo sapiens | ? | - |
? | |
| high molecular weight kininogen + H2O | - |
Homo sapiens | low molecular weight kininogen + bradykinin | - |
? | |
| additional information | zymogen undergoes autocatalytic activation | Homo sapiens | ? | - |
? | |
| platelet derived growth factor-AA + H2O | - |
Homo sapiens | ? | - |
? | |
| platelet derived growth factor-BB + H2O | - |
Homo sapiens | ? | - |
? | |
| tissue type plasminogen activator + H2O | - |
Homo sapiens | ? | - |
? | |
| vacular endothelial cell growth factor + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FASP | - |
Homo sapiens |
| HABP | - |
Homo sapiens |
| hyaluronic acid-binding protease | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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