EC Number   |
Activating Compound |
Reference |
|---|
   2.7.11.20 | 2-deoxy-D-glucose |
- |
665496 |
| 2.7.11.20 | 5-amino-4-imidazolecarboxyamide riboside |
- |
665496 |
| 2.7.11.20 | 5-hydroxytryptamine |
rapamycin activates the enzyme in neuron and antagonizes serotonin mediated by 5-hydroxytryptamine, rapamycin alone has no effect, but increases with 5-hydroxytryptamine the dephosphorylation of the eukaryotic elongation factor 2, 5-hydroxytryptamine decreases the phosphorylation of the eukaryotic elongation factor 2 at Thr57 in a rapamycin-sensitive manner, mechanism |
666113 |
| 2.7.11.20 | AICAR |
increases the levels of eEF2K phosphorylation more than 2fold |
680859 |
| 2.7.11.20 | bicuculline |
elevation of eEF2K activity with bicuculline, a GABA receptor antagonist |
740885 |
| 2.7.11.20 | calcium/calmodulin |
dependent on |
686390 |
| 2.7.11.20 | Calmodulin |
- |
664502, 760307, 760308, 760309, 760466, 760579, 760810, 761699, 762016 |
| 2.7.11.20 | Calmodulin |
a central mediator of Ca2+-dependent signaling, the enzyme is dependent on calmodulin |
739836 |
| 2.7.11.20 | Calmodulin |
absolutely necessary for efficient enzyme activity |
761472 |
| 2.7.11.20 | Calmodulin |
Ca2+/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr348 and Ser500 to regulate its activity and calcium dependence. At a calmodulin concentration of 0.002 mM, the enzyme exhibits significant activity |
721662 |
