EC Number   |
Activating Compound |
Reference  |
|---|
   2.7.10.2 | more |
Abl-SH3 domain is implicated in negative regulation of the Abl kinase by mediating protein-protein interactions. High-affinity SH3 ligands can compete for these interactions and specifically activate the Abl kinase |
490058 |
| 2.7.10.2 | more |
cellular counterpart of the viral v-fms oncogene product, the c-fms product, is the receptor for colony-stimulating factor 1 of macrophages, CSF-1. CSF-1 appeares to activate the serine/threonine kinase |
490099 |
| 2.7.10.2 | more |
tyrosine phosphorylation and association of ZAP-70 with zeta require the presence of src family PTKs |
490447 |
| 2.7.10.2 | more |
Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor beta-chain, but does not require the acidic domain that is required for association and activation of Src family kinases |
490629 |
| 2.7.10.2 | more |
ILK activity is rapidly, but transiently, stimulated upon attachment of cells to fibronectin, as well as by insulin, in a phosphoinositide-3-OH kinase-dependent manner. Furthermore, phosphatidylinositol(3,4,5)trisphosphate specifically stimulates the activity of ILK in vitro, and in addition, membrane targeted constitutively active Pi(3)K activates ILK in vivo |
491056 |
| 2.7.10.2 | NGF |
rapidly stimulates both Ser and Thr phosphorylation in vivo and autophosphorylation activity in vitro of the B-Raf protein |
492059 |
| 2.7.10.2 | more |
activation loop structure of Src and of Csk, autophosphorylation sites |
660885 |
| 2.7.10.2 | macrophage antigen-1 |
i.e. Mac1, a beta2-integrin activates Src PTKs Hck and Lyn, interaction of both requires Mn2+ |
660970 |
| 2.7.10.2 | more |
enzyme activity is induced by interleukin-8 in polymorphonuclear cells |
660970 |
| 2.7.10.2 | AMpYSSV |
CBP-based phosphopeptide, activates |
661180 |
