Activating Compound | Comment | Organism | Structure |
---|---|---|---|
macrophage antigen-1 | i.e. Mac1, a beta2-integrin activates Src PTKs Hck and Lyn, interaction of both requires Mn2+ | Homo sapiens | |
additional information | enzyme activity is induced by interleukin-8 in polymorphonuclear cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | i.e. pp2, inhibits Src family PTKs | Homo sapiens | |
additional information | enzyme interaction studies using inhibitory antibodies, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | activates, required for interaction between the Src family protein tyrosine kinase and the beta2-integrin macrophage antigen-1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [P-110]-L-tyrosine | Homo sapiens | - |
ADP + [P-110]-L-tyrosine phosphate | - |
? | |
additional information | Homo sapiens | Src-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells and required for adhesion of interleukin-8, Src PTKs are required for macrophage antigen-1-mediated adhesion, which is inhibited by cytochalasin D and involved F-actin and protein P-110, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
polymorphonuclear cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [P-110]-L-tyrosine | - |
Homo sapiens | ADP + [P-110]-L-tyrosine phosphate | - |
? | |
additional information | Src-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells and required for adhesion of interleukin-8, Src PTKs are required for macrophage antigen-1-mediated adhesion, which is inhibited by cytochalasin D and involved F-actin and protein P-110, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the Src PTK Pyk-2 is part of the P-110 protein | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
HCK | - |
Homo sapiens |
Lyn | - |
Homo sapiens |
More | Lyn, Hck, and Pyk-2 belong to the Src family of PTKs | Homo sapiens |
proline-rich tyrosine kinase-2 | - |
Homo sapiens |
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Homo sapiens |
Pyk-2 | - |
Homo sapiens |
Src | - |
Homo sapiens |