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Literature summary for 2.7.10.2 extracted from

  • Piccardoni, P.; Manarini, S.; Federico, L.; Bagoly, Z.; Pecce, R.; Martelli, N.; Piccoli, A.; Totani, L.; Cerletti, C.; Evangelista, V.
    SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells (2004), Biochem. J., 380, 57-65.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
macrophage antigen-1 i.e. Mac1, a beta2-integrin activates Src PTKs Hck and Lyn, interaction of both requires Mn2+ Homo sapiens
additional information enzyme activity is induced by interleukin-8 in polymorphonuclear cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine i.e. pp2, inhibits Src family PTKs Homo sapiens
additional information enzyme interaction studies using inhibitory antibodies, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ activates, required for interaction between the Src family protein tyrosine kinase and the beta2-integrin macrophage antigen-1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [P-110]-L-tyrosine Homo sapiens
-
ADP + [P-110]-L-tyrosine phosphate
-
?
additional information Homo sapiens Src-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells and required for adhesion of interleukin-8, Src PTKs are required for macrophage antigen-1-mediated adhesion, which is inhibited by cytochalasin D and involved F-actin and protein P-110, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
polymorphonuclear cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [P-110]-L-tyrosine
-
Homo sapiens ADP + [P-110]-L-tyrosine phosphate
-
?
additional information Src-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells and required for adhesion of interleukin-8, Src PTKs are required for macrophage antigen-1-mediated adhesion, which is inhibited by cytochalasin D and involved F-actin and protein P-110, overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More the Src PTK Pyk-2 is part of the P-110 protein Homo sapiens

Synonyms

Synonyms Comment Organism
HCK
-
Homo sapiens
Lyn
-
Homo sapiens
More Lyn, Hck, and Pyk-2 belong to the Src family of PTKs Homo sapiens
proline-rich tyrosine kinase-2
-
Homo sapiens
Protein tyrosine kinase
-
Homo sapiens
PTK
-
Homo sapiens
Pyk-2
-
Homo sapiens
Src
-
Homo sapiens