EC Number   |
Activating Compound |
Reference |
|---|
    4.1.1.9 | more |
MCD activity is elevated under conditions in which hepatic fatty acid oxidation is known to increase, such as streptozotocin-induced diabetes or following a 48 h fast, 2fold increase in expression in streptozotocin-diabetic rats compared with controls |
649690 |
| 4.1.1.9 | more |
peroxisomal-proliferator-activated receptor alpha activates transcription of hepatic MCD gene by binding of peroxisomal-proliferator-activated receptor alpha/retinoid X receptor alpha on two PPRE sites, WY14643-treated H4IIE hepatoma cells show increased MCD mRNA expression |
649775 |
| 4.1.1.9 | more |
there is an age-dependent increase in expression of MCD manifesting maturation of fatty acid metabolism in the newborn human heart |
694551 |
| 4.1.1.9 | palmitate |
the activity of MCD elicits a dose-dependent increase (between 25% and 60%) in cells exposed to increasing concentrations of palmitate (0.1-0.8 mM) |
693327 |
| 4.1.1.9 | phosphate |
activates |
4845 |
| 4.1.1.9 | WY-14643 |
specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle |
649300 |
