4.1.1.9 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A 652024 4.1.1.9 Alkaline phosphatase treatment with alkaline phosphatase enhances MCD activity suggesting phosphorylation-related control of enzyme 649690 4.1.1.9 AMP-activated potein kinase AMP-activated potein kinase activates MCD by phosphorylation 691964 4.1.1.9 DL-carnitine stimulates 4845 4.1.1.9 fatty acid increases MCD expression in heart and skeletal muscle 649300 4.1.1.9 fenofibrate increases hepatic mRNA expression and MCD activity 649775 4.1.1.9 iodoacetamide malonyl-decarboxylase activity is induced by treatment of fatty acid synthetase with iodoacetamide 4848 4.1.1.9 iodoacetamide treatment of fatty acid synthetase with iodoacetamide induces malonyl-CoA decarboxylase activity and impairs the synthetase activity 4855 4.1.1.9 additional information gastrocnemius contraction activates MCD, reversed by protein phosphatase A or by omitting phosphatase inhibitors from assay mixture, increase of MCD activity after skeletal muscle contraction is likely due to its phosphorylation by AMP-activated protein kinase 652024 4.1.1.9 additional information high-fat feeding, fasting and streptozotocin-induced diabetes increase the plasma concentration of nonesterified fatty acids, with a concomitant increase in both heart and skeletal muscle MCD mRNA 649300 4.1.1.9 additional information MCD activity is elevated under conditions in which hepatic fatty acid oxidation is known to increase, such as streptozotocin-induced diabetes or following a 48 h fast, 2fold increase in expression in streptozotocin-diabetic rats compared with controls 649690 4.1.1.9 additional information peroxisomal-proliferator-activated receptor alpha activates transcription of hepatic MCD gene by binding of peroxisomal-proliferator-activated receptor alpha/retinoid X receptor alpha on two PPRE sites, WY14643-treated H4IIE hepatoma cells show increased MCD mRNA expression 649775 4.1.1.9 additional information there is an age-dependent increase in expression of MCD manifesting maturation of fatty acid metabolism in the newborn human heart 694551 4.1.1.9 palmitate the activity of MCD elicits a dose-dependent increase (between 25% and 60%) in cells exposed to increasing concentrations of palmitate (0.1-0.8 mM) 693327 4.1.1.9 phosphate activates 4845 4.1.1.9 WY-14643 specifically stimulates the peroxisome proliferator-activated receptor-alpha increasing MCD expression and activity in heart and skeletal muscle 649300