EC Number   |
Activating Compound |
Reference |
|---|
   2.7.11.15 | cAMP-dependent protein kinase |
PKA-mediated phosphorylation favors subsequent phosphorylation of beta2-AR by beta-ARK, PKA increases the phosphorylation rate of beta-ARK |
645020 |
| 2.7.11.15 | Carbachol |
requirement, agonist, muscarinic cholinergic receptor as substrate |
645005 |
| 2.7.11.15 | cardiolipin |
activates, phosphorylation of beta2-AR |
645028 |
| 2.7.11.15 | corticotropin-releasing factor |
induces GRK2 expression in pituitary cells, suppressed by astressin, opposite effect compared to pituitary cells |
661606 |
| 2.7.11.15 | G protein |
binding and modulation of GRK2 and GRK3, Gbetagamma subunits bind GRK2 required for lipid association and G protein-coupled receptor phosphorylation and are released afterwards |
661455 |
| 2.7.11.15 | G protein |
binding of Gbeta/gamma dimers, activation is required for translocation from cytosol to plasma membrane |
662911 |
| 2.7.11.15 | G protein |
GRK2 binds G protein beta1gamma2 subunits, binding structure, no correct complex formation with recombinant Gbetagamma mutant C68S lacking the isoprenylation site, overview |
660579 |
| 2.7.11.15 | G protein |
GRK2 binds G protein beta1gamma2 subunits, binding structure, overview |
663391 |
| 2.7.11.15 | G protein |
interaction via GRK2 N-terminal RGS domain, binding of free Gbetagamma subunits initiates GRK2 translocation from cytosol to the plasma membrane and its activation for receptor phosphorylation |
662767 |
| 2.7.11.15 | G protein |
required for GRK2 activation |
662818 |
