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Literature summary for 2.7.11.15 extracted from

  • Moffett, S.; Rousseau, G.; Lagace, M.; Bouvier, M.
    The palmitoylation state of the beta2-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization (2001), J. Neurochem., 76, 269-279.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cAMP-dependent protein kinase PKA-mediated phosphorylation favors subsequent phosphorylation of beta2-AR by beta-ARK, PKA increases the phosphorylation rate of beta-ARK Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Bos taurus plays, together with cAMP-dependent protein kinase, an important role in agonist-promoted receptor desensitization, coordinated regulatory mechanism involving sequential depalmitoylation and phosphorylation of the beta2-AR by the two kinases ADP + phospho-beta-adrenergic receptor
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor human beta2-adrenergic receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor substrates: wild-type and mutants of beta2-AR, synergistic action of beta-ARK and cAMP-dependent protein kinase depends on the palmitoylation state of the receptor, putative phosphorylation sites of beta2-AR Bos taurus ADP + phospho-beta-adrenergic receptor
-
?
ATP + beta-adrenergic receptor plays, together with cAMP-dependent protein kinase, an important role in agonist-promoted receptor desensitization, coordinated regulatory mechanism involving sequential depalmitoylation and phosphorylation of the beta2-AR by the two kinases Bos taurus ADP + phospho-beta-adrenergic receptor
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Bos taurus