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Literature summary for 2.7.11.15 extracted from

  • Kageyama, K.; Hanada, K.; Moriyama, T.; Nigawara, T.; Sakihara, S.; Suda, T.
    G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophs (2006), Endocrinology, 147, 441-450.
    View publication on PubMed
Search for more literature for 2.7.11.15

Activating Compound

Activating Compound Comment Organism Structure
corticotropin-releasing factor induces GRK2 expression in pituitary cells, suppressed by astressin, opposite effect compared to pituitary cells Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of a dominant negative GRK2 mutant in AtT20 cells showing reduced CRFR1 desensitization Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
corticotropin-releasing factor reduces GRK2 expression in pituitary cells, suppressed by astressin, opposite effect compared to corticotroph tumor cells AtT20 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + corticotropin-releasing factor receptor type 1 Mus musculus i.e. CRFR1, phosphorylation leads to desensitization and downregulation of the receptor ADP + phosphorylated corticotropin-releasing factor receptor type 1
-
 ?
ATP + corticotropin-releasing factor receptor type 1 Rattus norvegicus i.e. CRFR1, phosphorylation leads to desensitization and downregulation of the receptor ADP + phosphorylated corticotropin-releasing factor receptor type 1
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
anterior pituitary gland GRK2, no expression of GRK3 Mus musculus
-
anterior pituitary gland no expression of GRK3 Rattus norvegicus
-
AtT-20 cell corticotroph tumor cell line, GRK2, no expression of GRK3 Mus musculus
-
corticotropic cell GRK2 Mus musculus
-
corticotropic cell GRK2 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + corticotropin-releasing factor receptor type 1
-
 Mus musculus ADP + phosphorylated corticotropin-releasing factor receptor type 1
-
 ?
ATP + corticotropin-releasing factor receptor type 1
-
 Rattus norvegicus ADP + phosphorylated corticotropin-releasing factor receptor type 1
-
 ?
ATP + corticotropin-releasing factor receptor type 1 i.e. CRFR1, phosphorylation leads to desensitization and downregulation of the receptor Mus musculus ADP + phosphorylated corticotropin-releasing factor receptor type 1
-
 ?
ATP + corticotropin-releasing factor receptor type 1 i.e. CRFR1, phosphorylation leads to desensitization and downregulation of the receptor Rattus norvegicus ADP + phosphorylated corticotropin-releasing factor receptor type 1
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 2
-
 Mus musculus
G protein-coupled receptor kinase 2
-
 Rattus norvegicus
GRK2
-
 Mus musculus
GRK2
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus