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Gene ontology
Version 2014-12-22
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Details for glutamate-cysteine ligase activity
6.3.2.2
Gene ontology ID
GO:0004357
Definition
Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate
Synonyms
1. gamma-glutamyl-L-cysteine synthetase activity
2. gamma-glutamylcysteine synthetase activity
3. gamma-glutamylcysteinyl synthetase activity
4. L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity
References
1. EC 6.3.2.2
2. RHEA: 13285
3. KEGG REACTION: R00894
4. MetaCyc GLUTCYSLIG-RXN
5. Reactome: R-HSA-174367 "GCL ligates L-Glu to L-Cys"
6. Reactome: R-HSA-5602892 "Defective GCLC does not ligate L-Glu to L-Cys"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
ligase activity is a
ligase activity, forming carbon-nitrogen bonds is a
acid-amino acid ligase activity is a
glutamate-cysteine ligase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
beta-alanyl-dopamine synthase activity is a
delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity is a
ligase activity, forming carbon-carbon bonds is a
ligase activity, forming carbon-nitrogen bonds is a
(-)-jasmonoyl-isoleucine synthetase activity is a
5-(carboxyamino)imidazole ribonucleotide synthase activity is a
acid-amino acid ligase activity is a
2,3-dihydroxybenzoate-serine ligase activity is a
4-aminobenzoate amino acid synthetase activity is a
4-hydroxybenzoate amino acid synthetase activity is a
aerobactin synthase activity is a
aliphatic aldoxime dehydratase activity is a
benzoate amino acid synthetase activity is a
carnitine-CoA ligase activity is a
carnosine synthase activity is a
coenzyme F420-0 gamma-glutamyl ligase activity is a
coenzyme F420-0:L-glutamate ligase activity is a
coenzyme F420-1:gamma-L-glutamate ligase activity is a
coenzyme F420-2 alpha-glutamyl ligase activity is a
cyanophycin synthetase activity is a
cyclo-acetoacetyl-L-tryptophan synthetase activity is a
D-alanine-alanyl-poly(glycerolphosphate) ligase activity is a
D-alanine-D-alanine ligase activity is a
gamma-glutamylhistamine synthase activity is a
glutamate-cysteine ligase activity is a
homocarnosine synthase activity is a
homoglutathione synthase activity is a
indole-3-acetic acid amido synthetase activity is a
jasmonate-amino synthetase activity is a
L-amino-acid alpha-ligase activity is a
L-propargylglycine--L-glutamate ligase activity is a
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity is a
pantoate-beta-alanine ligase activity is a
phenylacetaldoxime dehydratase activity is a
phosphopantothenate--cysteine ligase activity is a
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity is a
tyrosine-arginine ligase activity is a
UDP-N-acetylmuramate-L-alanine ligase activity is a
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity is a
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity is a
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity is a
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity is a
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity is a
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity is a
vanillate amino acid synthetase activity is a
acid-ammonia (or amide) ligase activity is a
adenylosuccinate synthase activity is a
argininosuccinate synthase activity is a
biotin carboxylase activity is a
carbamoyl-phosphate synthase (ammonia) activity is a
carbon-nitrogen ligase activity, with glutamine as amido-N-donor is a
citrate-L-glutamate ligase activity is a
CTP synthase activity is a
cyclo-ligase activity is a
formate-dihydrofolate ligase activity is a
formate-tetrahydrofolate ligase activity is a
glutamate-methylamine ligase activity is a
imidazoleacetate-phosphoribosyldiphosphate ligase activity is a
indole-3-acetyl-glutamate synthetase activity is a
indole-3-acetyl-glycine synthetase activity is a
indole-3-acetyl-isoleucine synthetase activity is a
indole-3-acetyl-leucine synthetase activity is a
indole-3-acetyl-methionine synthetase activity is a
indole-3-acetyl-phenylalanine synthetase activity is a
indole-3-acetyl-proline synthetase activity is a
indole-3-acetyl-tryptophan synthetase activity is a
indole-3-acetyl-tyrosine synthetase activity is a
indole-3-acetyl-valine synthetase activity is a
jasmonoyl-leucine synthetase activity is a
jasmonoyl-valine synthetase activity is a
N-(4-aminobenzoyl)-L-glutamate synthetase activity is a
N-(4-hydroxybenzoyl)-L-glutamate synthetase activity is a
N-acetyl-L-aspartate-L-glutamate ligase activity is a
N-benzoyl-L-glutamate synthetase activity is a
N-vanillate-L-glutamate synthetase activity is a
nicotinate phosphoribosyltransferase activity is a
phosphoribosylamine-glycine ligase activity is a
ribose-5-phosphate-ammonia ligase activity is a
sulfinylpropanyl adenylate synthase is a
urea carboxylase activity is a
ligase activity, forming carbon-oxygen bonds is a
ligase activity, forming carbon-sulfur bonds is a
ligase activity, forming nitrogen-metal bonds is a
ligase activity, forming phosphoric ester bonds is a
O antigen ligase activity is a
tRNA-specific 2-thiouridylase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a