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Gene ontology
Version 2014-12-22
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Details for retroviral 3' processing activity
Gene ontology ID
GO:0044824
Definition
The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls
Comment
This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification.
Synonyms
1. 3' processing reaction
2. 3'-processing activity
References
1. PMID 22580823
2. Reactome: R-HSA-164522
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