Gene ontology ID
GO:0017108
Definition
Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis
Synonyms
1. 5' flap endonuclease activity
References
1. PMID 97782542. Reactome: R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA"
3. Reactome: R-HSA-174446 "Removal of remaining Flap from the C-strand"
4. Reactome: R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)"
5. Reactome: R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ"
6. Reactome: R-HSA-69152 "Removal of remaining Flap"
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