Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate
1. GOC: mah
2. EC 2.7.12.13. Reactome: R-HSA-5672969 "Phosphorylation of RAF"
4. Reactome: R-HSA-5674373 "MAP2Ks phosphorylate MAPK at the Golgi membrane"
5. Reactome: R-HSA-6802910 "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants"
6. Reactome: R-HSA-6802916 "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants"
7. Reactome: R-HSA-6802918 "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants"
8. Reactome: R-HSA-6802921 "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants"
9. Reactome: R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS"
10. Reactome: R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS"
11. Reactome: R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated"
12. Reactome: R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF"