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ATP + (Ap)npAp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + (Up)10pGp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + 5S rRNA-pCp
AMP + ?
-
-
-
?
ATP + AAAACAAAAGp
AMP + ?
-
-
?
ATP + AAAAUAAAAGCp
AMP + ?
ATP + AAAAUAAAAGp
AMP + ?
ATP + AAAAUAAAAGpCp
AMP + diphosphate + AAAAUAAAAGpC-2',3'-cyclic phosphate
ATP + AUGp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + CCCCACCCCGp
AMP + ?
ATP + CCCCCACCCCGCp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + DNA 5'-terminal-phosphate
AMP + AppDNA
-
RtcA also catalyzes adenylylation of 5'-phosphate ends of DNA strands to form AppDNA product
-
-
?
ATP + human U14 snoRNA
AMP + ?
ATP + oligodeoxyribonucleotide 3'-terminal phosphate
AMP + diphosphate + oligodeoxyribonucleotide-2',3'-cyclic-phosphate
500fold poorer substrate than oligoribonucleotide 3'-terminal phosphate
-
-
?
ATP + RNA 2'-terminal-phosphate
?
ATP + RNA 3'-terminal-phosphate
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic phosphate
-
RtcA catalyzes the synthesis of RNA 2',3'-cyclic phosphate ends via an ATP-dependent pathway comprising three nucleotidyl transfer steps: reaction of RtcA with ATP to form a covalent RtcA-(histidinyl-N)-AMP intermediate and release diphosphate, transfer of AMP from RtcA to an RNA 3'-phosphate to form an RNA(3')pp(5')A intermediate, and attack by the terminal nucleoside O2' on the 3'-phosphate to form an RNA 2',3'-cyclic phosphate product and release AMP
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphodiester
ATP + RNA 5'-terminal-phosphate
AMP + AppRNA
-
RtcA also catalyzes adenylylation of 5'-phosphate ends of RNA strands to form AppRNA product
-
-
?
ATP + tobacco mosaic virus RNA
AMP + ?
-
fragments modified by ligation of pGp, pAp, or pCp
-
?
ATP + tRNA-pNp
AMP + ?
-
-
-
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
ATPgammaS + RNA 3'-terminal-phosphate
AMP + thiodiphosphate + RNA terminal-2',3'-cyclic-phosphate
CTP + RNA 3'-terminal-phosphate
CMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
GTP + RNA 3'-terminal-phosphate
GMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
RNA-N3'p + ATP
RNA-N-2',3'-cyclic phosphate + AMP + diphosphate
-
-
-
-
ir
UTP + RNA 3'-terminal-phosphate
UMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
additional information
?
-
ATP + 5S rRNA
AMP + ?
-
-
?
ATP + 5S rRNA
AMP + ?
-
modified by ligation of [5'-P]pCp to the 3'-terminus
-
?
ATP + 5S rRNA
AMP + ?
-
-
?
ATP + AAAAUAAAAGCp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + AAAAUAAAAGCp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + AAAAUAAAAGp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + AAAAUAAAAGp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + AAAAUAAAAGpCp
AMP + diphosphate + AAAAUAAAAGpC-2',3'-cyclic phosphate
-
-
-
ir
ATP + AAAAUAAAAGpCp
AMP + diphosphate + AAAAUAAAAGpC-2',3'-cyclic phosphate
-
-
-
-
ir
ATP + CCCCACCCCGp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + CCCCACCCCGp
AMP + ?
-
pure oligoribonucleotide
-
?
ATP + human U14 snoRNA
AMP + ?
-
-
?
ATP + human U14 snoRNA
AMP + ?
-
modified by ligation of [5'-P]pCp to the 3'-terminus
-
?
ATP + human U14 snoRNA
AMP + ?
-
-
?
ATP + RNA 2'-terminal-phosphate
?
-
the rate of 2'-phosphate cyclization by RtcA is five orders of magnitude slower than 3'-phosphate cyclization, notwithstanding that RtcA binds with similar affinity to RNA3'p and RNA2'p substrates
-
-
?
ATP + RNA 2'-terminal-phosphate
?
-
-
-
-
?
ATP + RNA 3'-terminal-phosphate
?
the enzyme could be involved in the maintenance of cyclic ends in tRNA splicing intermediates or in the cyclization of the 3' end of U6 sbRNA
-
-
?
ATP + RNA 3'-terminal-phosphate
?
-
role in RNA processing
-
-
?
ATP + RNA 3'-terminal-phosphate
?
-
role in RNA processing
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
RtcA can quantitatively cyclize 8-mer, 6-mer, and 4-mer RNA3'p substrates
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
no activity with dATP
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
ir
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
(Up)10Gp is cyclized at a faster rate than tRNAApGp or AUGp
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
human U6 small nuclear RNA
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
oligoribonucleotides
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphodiester
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphodiester
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphodiester
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphodiester
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphodiester
-
-
-
?
ATP + RNA 3'-terminal-phosphate
AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphodiester
-
-
-
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
-
-
-
-
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
-
-
-
-
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
ATPgammaS + RNA 3'-terminal-phosphate
AMP + thiodiphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
-
?
ATPgammaS + RNA 3'-terminal-phosphate
AMP + thiodiphosphate + RNA terminal-2',3'-cyclic-phosphate
-
ir
-
?
CTP + RNA 3'-terminal-phosphate
CMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
-
?
CTP + RNA 3'-terminal-phosphate
CMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
reaction proceeds 15-20 times slower than in presence of ATP
-
-
?
GTP + RNA 3'-terminal-phosphate
GMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
-
?
GTP + RNA 3'-terminal-phosphate
GMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
-
?
GTP + RNA 3'-terminal-phosphate
GMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
reaction proceeds 15-20 times slower than in presence of ATP
-
-
?
UTP + RNA 3'-terminal-phosphate
UMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
-
-
-
?
UTP + RNA 3'-terminal-phosphate
UMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate
-
reaction proceeds 15-20 times slower than in presence of ATP
-
-
?
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
-
-
-
-
?
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
-
-
-
-
?
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
-
-
-
-
?
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
-
-
-
-
?
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
-
-
-
-
?
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
-
-
-
-
?
additional information
?
-
-
nucleoside 3'-monophosphates and nucleoside 5',3'-bisphosphates are no substrates
-
?
additional information
?
-
nonessential as demonstrated by knockout experiments
-
?
additional information
?
-
-
nonessential as demonstrated by knockout experiments
-
?
additional information
?
-
precise function is not known, may be responsible for generating or regenerating cyclic phosphate RNA ends required by RNA ligases
-
?
additional information
?
-
-
precise function is not known, may be responsible for generating or regenerating cyclic phosphate RNA ends required by RNA ligases
-
?
additional information
?
-
-
RtcA readily adenylylates the 5'-phosphate at a 5'-PO4/3'-OH nick in duplex DNA but is unable to covert the nicked DNA-adenylate to a sealed phosphodiester
-
-
?
additional information
?
-
-
the enzyme is incapable of phosphodiester synthesis (i.e., ligation) following adenylation of the 5'-terminal phosphate
-
-
?
additional information
?
-
nonessential as demonstrated by knockout experiments
-
?
additional information
?
-
-
ATP/diphosphate exchange reaction not detected
-
-
?
additional information
?
-
-
trinucleotides are the shortest oligonucleotides able to act as substrates, ribonucleoside 3'-phosphates and ribonucleoside 5',3'-phosphates are no substrates
-
?
additional information
?
-
-
the enzyme is incapable of phosphodiester synthesis (i.e., ligation) following adenylation of the 5'-terminal phosphate
-
-
?
additional information
?
-
-
the enzyme is also able to convert DNA-3'-phosphate to single-stranded DNA-3'-diphosphate-5'-adenylate but not able to modify a 3'-phosphate in nicked double-stranded DNA
-
-
?
additional information
?
-
the enzyme recognizes substrate RNA by ensuring that the terminal 3'-phosphate makes a large contribution to RNA binding
-
-
?
additional information
?
-
-
the enzyme recognizes substrate RNA by ensuring that the terminal 3'-phosphate makes a large contribution to RNA binding
-
-
?
additional information
?
-
the enzyme recognizes substrate RNA by ensuring that the terminal 3'-phosphate makes a large contribution to RNA binding
-
-
?
additional information
?
-
-
it was suggested that the enzyme could be responsible for the generation of the 2',3'-cyclic termini required for ligation of RNA by eukaryotic ligases and, consequently, be involved in tRNA slicing. It was found, however, that the slicing endonucleases responsible for the excision of introns from tRNA precursors in yeast and Xenopus sp. directly produce RNA molecules with cyclic phosphate ends
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + RNA 3'-terminal-phosphate
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
additional information
?
-
ATP + RNA 3'-terminal-phosphate
?
the enzyme could be involved in the maintenance of cyclic ends in tRNA splicing intermediates or in the cyclization of the 3' end of U6 sbRNA
-
-
?
ATP + RNA 3'-terminal-phosphate
?
-
role in RNA processing
-
-
?
ATP + RNA 3'-terminal-phosphate
?
-
role in RNA processing
-
-
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
-
-
-
-
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
-
-
-
-
?
ATP + [RNA 3'-phosphate cyclase]-L-histidine
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
ATP + [RNA]-3'-(3'-phospho-ribonucleoside)
AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside
-
-
-
-
?
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
-
-
-
-
?
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
-
-
-
-
?
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside)
[RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
-
-
-
-
?
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
-
-
-
-
?
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
-
-
-
-
?
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
-
-
-
-
?
additional information
?
-
nonessential as demonstrated by knockout experiments
-
?
additional information
?
-
-
nonessential as demonstrated by knockout experiments
-
?
additional information
?
-
precise function is not known, may be responsible for generating or regenerating cyclic phosphate RNA ends required by RNA ligases
-
?
additional information
?
-
-
precise function is not known, may be responsible for generating or regenerating cyclic phosphate RNA ends required by RNA ligases
-
?
additional information
?
-
nonessential as demonstrated by knockout experiments
-
?
additional information
?
-
-
it was suggested that the enzyme could be responsible for the generation of the 2',3'-cyclic termini required for ligation of RNA by eukaryotic ligases and, consequently, be involved in tRNA slicing. It was found, however, that the slicing endonucleases responsible for the excision of introns from tRNA precursors in yeast and Xenopus sp. directly produce RNA molecules with cyclic phosphate ends
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Reinberg, D.; Arenas, J.; Hurwitz, J.
The enzymatic conversion of 3'-phosphate terminated RNA chains to 2',3'-cyclic phosphate derivatives
J. Biol. Chem.
260
6088-6097
1985
Homo sapiens
brenda
Filipowicz, W.; Konarska, M.; Gross, H.J.; Shatkin, A.J.
RNA 3'-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract
Nucleic Acids Res.
11
1405-1418
1983
Homo sapiens, Xenopus laevis
brenda
Vicente, O.; Filipowicz, W.
Purification of RNA 3'-terminal phosphate cyclase from HeLa cells
Eur. J. Biochem.
17
431-439
1988
Homo sapiens
brenda
Filipowicz, W.; Vicente, O.
RNA 3'-terminal phosphate cyclase from HeLa cells
Methods Enzymol.
181
499-510
1990
Homo sapiens, Xenopus laevis
brenda
Genschik, P.; Billy, E.; Swianiewicz, M.; Filipowicz, W.
The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in eucarya, bacteria and archaea
EMBO J.
16
2955-2967
1997
Homo sapiens (O00442), Homo sapiens
brenda
Gu, J.; Shumyatsky, G.; Makan, N.; Reddy, R.
Formation of 2',3'-cyclic phosphates at the 3' end of human U6 small nuclear RNA in vitro. Identification of 2',3'-cyclic phosphates at the 3' ends of human signal recognition particle and mitochondrial RNA processing RNAs
J. Biol. Chem.
272
21989-21993
1997
Homo sapiens
brenda
Filipowicz, W.; Billy, E.; Drabikowski, K.; Genschik, P.
Cyclases of the 3'-terminal phosphate in RNA: a new family of RNA processing enzymes conserved in Eucarya, Bacteria and Archaea
Acta Biochim. Pol.
45
895-906
1998
Aquifex aeolicus, Arabidopsis thaliana, Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii, Mus musculus, no activity in Bacillus subtilis, no activity in Haemophilus influenzae, no activity in Mycoplasma genitalium, no activity in Synechocystis sp., Pseudomonas aeruginosa, Schizosaccharomyces pombe, Toxoplasma gondii, Xenopus sp., no activity in Helicobacter pylori
brenda
Billy, E.; Wegierski, T.; Nasr, F.; Filipowicz, W.
Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis
EMBO J.
19
2115-2126
2000
Homo sapiens, Mus musculus, Saccharomyces cerevisiae
brenda
Genschik, P.; Drabikowski, K.; Filipowicz, W.
Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon
J. Biol. Chem.
273
25516-25526
1998
Escherichia coli (P46850), Escherichia coli, Escherichia coli YMC10 (P46850)
brenda
Billy, E.; Hess, D.; Hofsteenge, J.; Filipowicz, W.
Characterization of the adenylation site in the RNA 3'-terminal phosphate cyclase from Escherichia coli
J. Biol. Chem.
274
34955-34960
1999
Escherichia coli (P46849), Escherichia coli
brenda
Palm, G.J.; Billy, E.; Filipowicz, W.; Wlodawer, A.
Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology
Structure Fold. Des.
8
13-23
2000
Escherichia coli (P46849), Escherichia coli
brenda
Shimizu, S.; Ohki, M.; Ohkubo, N.; Suzuki, K.; Tsunoda, M.; Sekiguchi, T.; Takenaka, A.
Crystal structures of RNA 3-terminal phosphate cyclase and its complexes with Mg2+ +ATP, ATP or Mn2+
Nucleic Acids Symp. Ser.
52
221-222
2008
Sulfurisphaera tokodaii
brenda
Shimizu, S.; Ohki, M.; Okubo, N.; Suzuki, K.; Tsunoda, M.; Sekiguchi, T.; Takenaka, A.
Crystallization and preliminary crystallographic studies of putative RNA 3-terminal phosphate cyclase from the crenarchaeon Sulfolobus tokodaii
Acta Crystallogr. Sect. F
65
565-570
2009
Sulfurisphaera tokodaii
brenda
Tanaka, N.; Shuman, S.
Structure-activity relationships in human RNA 3-phosphate cyclase
RNA
15
1865-1874
2009
Homo sapiens, Escherichia coli (P46849), Escherichia coli
brenda
Tanaka, N.; Smith, P.; Shuman, S.
Structure of the RNA 3-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer
Structure
18
449-457
2010
Escherichia coli (P46849)
brenda
Chakravarty, A.K.; Shuman, S.
RNA 3'-phosphate cyclase (RtcA) catalyzes ligase-like adenylylation of DNA and RNA 5'-monophosphate ends
J. Biol. Chem.
286
4117-4122
2011
Escherichia coli
brenda
Das, U.; Shuman, S.
2-Phosphate cyclase activity of RtcA: a potential rationale for the operon organization of RtcA with an RNA repair ligase RtcB in Escherichia coli and other bacterial taxa
RNA
19
1355-1362
2013
Escherichia coli, Homo sapiens
brenda
Desai, K.K.; Bingman, C.A.; Cheng, C.L.; Phillips, G.N. Jr.; Raines, R.T.
Structure of RNA 3'-phosphate cyclase bound to substrate RNA
RNA
20
1560-1566
2014
Pyrococcus horikoshii (O59198), Pyrococcus horikoshii, Pyrococcus horikoshii DSM 12428 (O59198)
brenda
Maughan, W.P.; Shuman, S.
Characterization of 3-phosphate RNA ligase paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus highlights DNA and RNA 5-phosphate capping activity of RtcB3
J. Bacteriol.
197
3616-3624
2015
Myxococcus xanthus
brenda
Zhelkovsky, A.M.; McReynolds, L.A.
Polynucleotide 3-terminal phosphate modifications by RNA and DNA ligases
J. Biol. Chem.
289
33608-33616
2014
Methanothermobacter thermautotrophicus
brenda
Filipowicz, W.
RNA 3-terminal phosphate cyclases and cyclase-like proteins
Postepy Biochem.
62
327-334
2016
Escherichia coli, Homo sapiens
brenda