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Information on EC 6.3.2.54 - L-2,3-diaminopropanoate-citrate ligase

for references in articles please use BRENDA:EC6.3.2.54

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IUBMB Comments

Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.

The enzyme appears in viruses and cellular organisms

Synonyms
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate synthtase, sbnE, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + L-2,3-diaminopropanoate + citrate = AMP + diphosphate + 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate
show the reaction diagram
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Highest Expressing Human Cell Lines
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