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EC Tree
IUBMB Comments The enzyme, characterized from the archaeon Methanosarcina mazei, is involved in the biosynthesis of pantothenate. It is different from EC 6.3.2.1, the AMP-forming pantoate-beta-alanine ligase found in bacteria and eukaryota.
The enzyme appears in viruses and cellular organisms
Synonyms
MM2281, Pantothenate synthetase,
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MM2281
locus name
Pantothenate synthetase
ambiguous
Pantothenate synthetase
ambiguous
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ATP + (R)-pantoate + beta-alanine = ADP + phosphate + (R)-pantothenate
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(R)-pantoate:beta-alanine ligase (ADP-forming)
The enzyme, characterized from the archaeon Methanosarcina mazei, is involved in the biosynthesis of pantothenate. It is different from EC 6.3.2.1, the AMP-forming pantoate-beta-alanine ligase found in bacteria and eukaryota.
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ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
the enzyme is involved in the biosynthesis of pantothenate
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?
ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
purified enzyme shows no activity on its own, but the enzyme enables substantial synthesis of 4'-phosphopantothenate from beta-alanine, pantoate and ATP when coupled with Escherichia coli pantothenate kinase
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ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
the enzyme is involved in the biosynthesis of pantothenate
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-
?
ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
purified enzyme shows no activity on its own, but the enzyme enables substantial synthesis of 4'-phosphopantothenate from beta-alanine, pantoate and ATP when coupled with Escherichia coli pantothenate kinase
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?
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ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
the enzyme is involved in the biosynthesis of pantothenate
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?
ATP + (R)-pantoate + beta-alanine
ADP + phosphate + (R)-pantothenate
the enzyme is involved in the biosynthesis of pantothenate
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?
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(R)-pantothenate
strong product inhibition
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SwissProt
brenda
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SwissProt
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physiological function
the enzyme is involved in the biosynthesis of pantothenate
physiological function
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the enzyme is involved in the biosynthesis of pantothenate
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A0A5E4IYT9_9ARCH
176
0
19363
TrEMBL
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PPS_METMA
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
253
0
27594
Swiss-Prot
-
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30000
2 * 30000, SDS-PAGE
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dimer
2 * 30000, SDS-PAGE
dimer
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2 * 30000, SDS-PAGE
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expression in Escherichia coli as a N-terminally His-tag fusion protein
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Ronconi, S.; Jonczyk, R.; Genschel, U.
A novel isoform of pantothenate synthetase in the Archaea
FEBS J.
275
2754-2764
2008
Methanosarcina mazei (Q8PUQ1), Methanosarcina mazei, Methanosarcina mazei DSM 3647 (Q8PUQ1)
brenda
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