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Information on EC 5.4.99.45 - tRNA pseudouridine38/39 synthase

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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.45 tRNA pseudouridine38/39 synthase
IUBMB Comments
The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC 5.4.99.12, tRNA pseudouridine38-40 synthase) . In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu) .
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
tRNA uridine38/39
=
tRNA pseudouridine38/39
Synonyms
Deg1, Deg1p, mPus3p, pseudouridine synthase 3, PUS3, PUS3/DEG1, Pus3p, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tRNA uridine38/39 = tRNA pseudouridine38/39
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