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BRENDA support

Information on EC 4.4.1.35 - L-cystine beta-lyase

for references in articles please use BRENDA:EC4.4.1.35

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IUBMB Comments

A pyridoxal 5'-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-thiocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from Brassica oleracea var. italica (broccoli) does not act on cysteine or cystathionine.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
cori3, bocl3, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-aminoprop-2-enoate = 2-iminopropanoate
show the reaction diagram
(1b), spontaneous
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2-iminopropanoate + H2O = pyruvate + NH3
show the reaction diagram
(1c), spontaneous
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L-cystine + H2O = L-thiocysteine + pyruvate + NH3
show the reaction diagram
overall reaction
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L-cystine = L-thiocysteine + 2-aminoprop-2-enoate
show the reaction diagram
(1a)
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PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links