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Information on EC 4.2.3.152 - 2-epi-5-epi-valiolone synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.152 2-epi-5-epi-valiolone synthase
IUBMB Comments
The enzyme is highly specific for alpha-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
AbcC, AcbC, C7-cyclitol synthase, CetA, EVS, SalQ, sedoheptulose 7-phosphate cyclase, SH7PC, ValA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha-D-sedoheptulopyranose 7-phosphate = 2-epi-5-epi-valiolone + phosphate
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