Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2R,3S)-2-methyl-3-hydroxysuccinyl-C4-CoA + H2O
3-methylfumaryl-CoA + H2O
i.e. (S)-citramalyl-CoA
-
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
(S)-citramalyl-CoA
3-methylfumaryl-CoA + H2O
-
-
-
r
(S)-malyl-CoA
fumaryl-CoA + H2O
-
-
-
r
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
3-methylfumaryl-CoA + H2O
(S)-citramalyl-CoA
i.e. mesaconyl-C4-CoA
-
-
r
fumaryl-CoA + H2O
(S)-malyl-CoA
-
-
-
r
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
mesaconyl-C4-CoA + H2O
(2R,3S)-2-methyl-3-hydroxysuccinyl-C4-CoA + H2O
EC 4.2.1.153
-
-
r
additional information
?
-
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
-
the enzyme is part of the 3-hydroxypropanoate cycle for carbon assimilation
-
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
-
(2R,3S)-2-methylmalyl-CoA i.e. L-erythro-beta-methylmalyl-CoA = (2R,3S)-2-methyl-3-carboxy-3-hydroxypropanoyl-CoA
2-methylfumaryl-CoA i.e. (E)-3-carboxy-2-methylprop-2-enoyl-CoA
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
the enzyme is part of the 3-hydroxypropanoate cycle for carbon assimilation
-
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA i.e. L-erythro-beta-methylmalyl-CoA = (2R,3S)-2-methyl-3-carboxy-3-hydroxypropanoyl-CoA
2-methylfumaryl-CoA i.e. (E)-3-carboxy-2-methylprop-2-enoyl-CoA
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
the equilibrium of the reaction is on the side of (2R,3S)-2-methylmalyl-CoA
-
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
the equilibrium of the reaction is on the side of (2R,3S)-2-methylmalyl-CoA
-
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
the equilibrium of the reaction is on the side of (2R,3S)-2-methylmalyl-CoA
-
-
r
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA. The enzyme catalyzes a reaction in the methylaspartate cycle
-
-
?
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA, i.e. mesaconyl-C1-CoA. The equilibrium of the reaction is on the side of (2R,3S)-2-methylmalyl-CoA
-
-
r
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA. The enzyme catalyzes a reaction in the methylaspartate cycle
-
-
?
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA, i.e. mesaconyl-C1-CoA. The equilibrium of the reaction is on the side of (2R,3S)-2-methylmalyl-CoA
-
-
r
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA. The enzyme catalyzes a reaction in the methylaspartate cycle
-
-
?
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA, i.e. mesaconyl-C1-CoA. The equilibrium of the reaction is on the side of (2R,3S)-2-methylmalyl-CoA
-
-
r
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
the physiological substrate is mesaconyl-C1-CoA
-
-
r
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
hydration of mesaconyl-C1-CoA to (2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA (erythro-beta-methylmalyl-CoA), EC 4.2.1.148. The activity for hydration of mesaconyl-C1-CoA is an order of magnitude higher for the reverse reaction of beta-methylmalyl-CoA dehydration
-
-
r
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
the physiological substrate is mesaconyl-C1-CoA
-
-
r
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
the physiological substrate is mesaconyl-C1-CoA
-
-
r
additional information
?
-
recombinant mesaconyl-CoA hydratase has a 3.5fold bias for the physiological substrate, mesaconyl-C1-CoA, compared to mesaconyl-C4-CoA. The enzyme is also active with mesaconyl-C4-CoA, (S)-citramalyl-CoA and (S)-malyl-CoA, and virtually has no activity with other tested enoyl-CoA/3-hydroxyacyl-CoA compounds. The enzyme activity is an order of magnitude higher for mesaconyl-C1-CoA/beta-methylmalyl-CoA compared to other substrates
-
-
?
additional information
?
-
-
recombinant mesaconyl-CoA hydratase has a 3.5fold bias for the physiological substrate, mesaconyl-C1-CoA, compared to mesaconyl-C4-CoA. The enzyme is also active with mesaconyl-C4-CoA, (S)-citramalyl-CoA and (S)-malyl-CoA, and virtually has no activity with other tested enoyl-CoA/3-hydroxyacyl-CoA compounds. The enzyme activity is an order of magnitude higher for mesaconyl-C1-CoA/beta-methylmalyl-CoA compared to other substrates
-
-
?
additional information
?
-
recombinant mesaconyl-CoA hydratase has a 3.5fold bias for the physiological substrate, mesaconyl-C1-CoA, compared to mesaconyl-C4-CoA. The enzyme is also active with mesaconyl-C4-CoA, (S)-citramalyl-CoA and (S)-malyl-CoA, and virtually has no activity with other tested enoyl-CoA/3-hydroxyacyl-CoA compounds. The enzyme activity is an order of magnitude higher for mesaconyl-C1-CoA/beta-methylmalyl-CoA compared to other substrates
-
-
?
additional information
?
-
recombinant mesaconyl-CoA hydratase has a 3.5fold bias for the physiological substrate, mesaconyl-C1-CoA, compared to mesaconyl-C4-CoA. The enzyme is also active with mesaconyl-C4-CoA, (S)-citramalyl-CoA and (S)-malyl-CoA, and virtually has no activity with other tested enoyl-CoA/3-hydroxyacyl-CoA compounds. The enzyme activity is an order of magnitude higher for mesaconyl-C1-CoA/beta-methylmalyl-CoA compared to other substrates
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
-
the enzyme is part of the 3-hydroxypropanoate cycle for carbon assimilation
-
-
r
(2R,3S)-2-methylmalyl-CoA
2-methylfumaryl-CoA + H2O
the enzyme is part of the 3-hydroxypropanoate cycle for carbon assimilation
-
-
r
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA. The enzyme catalyzes a reaction in the methylaspartate cycle
-
-
?
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA. The enzyme catalyzes a reaction in the methylaspartate cycle
-
-
?
2-methylfumaryl-CoA + H2O
(2R,3S)-2-methylmalyl-CoA
i.e. mesaconyl-CoA. The enzyme catalyzes a reaction in the methylaspartate cycle
-
-
?
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
the physiological substrate is mesaconyl-C1-CoA
-
-
r
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
the physiological substrate is mesaconyl-C1-CoA
-
-
r
mesaconyl-C1-CoA
(2R,3S)-2-methyl-3-hydroxysuccinyl-C1-CoA + H2O
the physiological substrate is mesaconyl-C1-CoA
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
evolution
the mch gene is mainly transmitted vertically among haloarchaea
evolution
the methylaspartate cycle is discovered in Haloarcula spp. and operates in about 40% of sequenced haloarchaea. Mesaconate CoA-transferase and mesaconyl-CoA hydratase are the characteristic enzymes of this cycle. Phylogenetic analysis
evolution
-
the mch gene is mainly transmitted vertically among haloarchaea
-
evolution
-
the methylaspartate cycle is discovered in Haloarcula spp. and operates in about 40% of sequenced haloarchaea. Mesaconate CoA-transferase and mesaconyl-CoA hydratase are the characteristic enzymes of this cycle. Phylogenetic analysis
-
evolution
-
the mch gene is mainly transmitted vertically among haloarchaea
-
evolution
-
the methylaspartate cycle is discovered in Haloarcula spp. and operates in about 40% of sequenced haloarchaea. Mesaconate CoA-transferase and mesaconyl-CoA hydratase are the characteristic enzymes of this cycle. Phylogenetic analysis
-
metabolism
mesaconate (methylfumarate) that needs to be activated to mesaconyl-C1-CoA and hydrated to beta-methylmalyl-CoA in the methylaspartate cycle as part of the anaplerotic pathway for the conversion of acetyl-CoA into cellular building blocks. The cleavage of beta-methylmalyl-CoA results in the formation of propionyl-CoA and glyoxylate. The carboxylation of propionyl-CoA and the condensation of glyoxylate with another acetyl-CoA molecule give rise to two C4-dicarboxylic acids, thus regenerating the initial acetyl-CoA acceptor and forming malate, its final product. The methylaspartate cycle, overview
metabolism
the enzyme catalyzes a reaction in the methylaspartate cycle
metabolism
-
mesaconate (methylfumarate) that needs to be activated to mesaconyl-C1-CoA and hydrated to beta-methylmalyl-CoA in the methylaspartate cycle as part of the anaplerotic pathway for the conversion of acetyl-CoA into cellular building blocks. The cleavage of beta-methylmalyl-CoA results in the formation of propionyl-CoA and glyoxylate. The carboxylation of propionyl-CoA and the condensation of glyoxylate with another acetyl-CoA molecule give rise to two C4-dicarboxylic acids, thus regenerating the initial acetyl-CoA acceptor and forming malate, its final product. The methylaspartate cycle, overview
-
metabolism
-
the enzyme catalyzes a reaction in the methylaspartate cycle
-
metabolism
-
mesaconate (methylfumarate) that needs to be activated to mesaconyl-C1-CoA and hydrated to beta-methylmalyl-CoA in the methylaspartate cycle as part of the anaplerotic pathway for the conversion of acetyl-CoA into cellular building blocks. The cleavage of beta-methylmalyl-CoA results in the formation of propionyl-CoA and glyoxylate. The carboxylation of propionyl-CoA and the condensation of glyoxylate with another acetyl-CoA molecule give rise to two C4-dicarboxylic acids, thus regenerating the initial acetyl-CoA acceptor and forming malate, its final product. The methylaspartate cycle, overview
-
metabolism
-
the enzyme catalyzes a reaction in the methylaspartate cycle
-
physiological function
-
the enzyme is part of the 3-hydroxypropanoate cycle for carbon assimilation
physiological function
the enzyme is part of the 3-hydroxypropanoate cycle for carbon assimilation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Zarzycki, J.; Schlichting, A.; Strychalsky, N.; Muller, M.; Alber, B.E.; Fuchs, G.
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria
J. Bacteriol.
190
1366-1374
2008
Cereibacter sphaeroides, Chloroflexus aurantiacus (A9WC34), Chloroflexus aurantiacus
brenda
Borjian, F.; Johnsen, U.; Schoenheit, P.; Berg, I.A.
Succinyl-CoA mesaconate CoA-transferase and mesaconyl-CoA hydratase, enzymes of the methylaspartate cycle in Haloarcula hispanica
Front. Microbiol.
8
1683
2017
Haloarcula hispanica (G0HQ35), Haloarcula hispanica, Haloarcula hispanica ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755 (G0HQ35), Haloarcula hispanica DSM 4426 (G0HQ35)
brenda