Information on EC 3.5.1.111 - 2-oxoglutaramate amidase

for references in articles please use BRENDA:EC3.5.1.111
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The expected taxonomic range for this enzyme is: Paenarthrobacter nicotinovorans

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EC NUMBER
COMMENTARY hide
3.5.1.111
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RECOMMENDED NAME
GeneOntology No.
2-oxoglutaramate amidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-oxoglutaramate + H2O = 2-oxoglutarate + NH3
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
nicotine degradation I (pyridine pathway)
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S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation
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Alanine, aspartate and glutamate metabolism
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SYSTEMATIC NAME
IUBMB Comments
5-amino-2,5-dioxopentanoate amidohydrolase
The enzyme, which is highly specific for its substrate, participates in the nicotine degradation pathway of several Gram-positive bacteria.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxoglutaramate + H2O
?
show the reaction diagram
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?
L-glutamic acid + H2O
?
show the reaction diagram
poor substrate
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?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.3
2-Oxoglutaramate
pH 7.1, 30 °C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
194
2-Oxoglutaramate
pH 7.1, 30 °C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32300
calculated from cDNA
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homotetramer
4 * 32300, gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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Show AA Sequence (309 entries)
Please use the Sequence Search for a specific query.
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LINKS TO OTHER DATABASES (specific for EC-Number 3.5.1.111)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)