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Type IV collagen + H2O
?
-
-
-
?
von Willebrand factor + H2O
?
-
-
-
?
Abz-LVEALYQ-EDDnp + H2O
?
-
-
-
-
?
alpha2 subunit I domain of the platelet surface alpha2beta1 integrin + H2O
?
-
-
-
-
?
alpha2-Plasmin inhibitor + H2O
Inactivated alpha2-plasmin inhibitor
-
-
-
?
azocasein + H2O
?
-
-
-
-
?
casein + H2O
hydrolyzed casein
-
-
-
?
F-actin + H2O
G-actin + ?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
focal adhesion kinase + H2O
?
-
-
-
-
?
FVNQHLCGSHLVEALYVCGERGFFYTPKA + H2O
FVNQHLCGSH + Lys-Val-Glu-Ala + Lys + YVCGERGF + FYTPKA
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Nidogen + H2O
?
-
degradation, preferred substrate
-
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed oxidized insulin B-chain
-
cleavage at 4 peptide bonds
-
?
platelet collagen receptor integrin alpha2beta1 + H2O
?
-
-
-
-
?
Type I collagen + H2O
?
-
-
-
-
?
von Willebrand factor + H2O
?
additional information
?
-
Fibrinogen + H2O
?
-
-
-
?
Fibrinogen + H2O
?
bovine substrate
-
-
?
Type I collagen + H2O
?
-
-
-
?
Type I collagen + H2O
?
bovine and chicken substrates, the enzyme binds with high affinity to the intact triple helix collagen structure affecting the collagen suprastructure
-
-
?
collagen XII + H2O
?
-
-
-
-
?
collagen XII + H2O
?
-
bovine substrate, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview
-
-
?
collagen XII + H2O
?
-
the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis
-
-
?
collagen XIV + H2O
?
-
-
-
-
?
collagen XIV + H2O
?
-
bovine substrate, a fibril-associated collagen with interrupted triple helices, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview
-
-
?
collagen XIV + H2O
?
-
the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis
-
-
?
Fibrinogen + H2O
?
-
-
-
-
?
Fibrinogen + H2O
?
-
bovine substrate
-
-
?
Laminin + H2O
?
-
-
-
-
?
Laminin + H2O
?
-
degradation
-
-
?
Laminin + H2O
?
-
degradation of alpha1, beta1, and gamma1 chains
-
-
?
matrilin 1 + H2O
?
-
-
-
-
?
matrilin 1 + H2O
?
-
bovine substrate, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains
-
-
?
matrilin 1 + H2O
?
-
the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis
-
-
?
matrilin 3 + H2O
?
-
-
-
-
?
matrilin 3 + H2O
?
-
the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis
-
-
?
matrilin 3 + H2O
?
-
the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview
-
-
?
matrilin 4 + H2O
?
-
-
-
-
?
matrilin 4 + H2O
?
-
the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis
-
-
?
matrilin 4 + H2O
?
-
the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains
-
-
?
Type IV collagen + H2O
?
-
-
-
-
?
Type IV collagen + H2O
?
-
degradation
-
-
?
von Willebrand factor + H2O
?
-
-
-
-
?
von Willebrand factor + H2O
?
-
binding between jararhagin cysteine-rich domain and Von Willebrand factor A1 domain leads to inhibition of Von Willebrand factor platelet aggregation activity, overview
-
-
?
von Willebrand factor + H2O
?
-
Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at sites adjacent to the A1 domain
-
-
?
von Willebrand factor + H2O
?
-
mapping of Von Willebrand factor A domain binding sites on the enzyme's cysteine-rich domain, binding between jararhagin cysteine-rich domain and Von Willebrand factor A1 domain, protein-protein interactions, molecular modeling, overview
-
-
?
von Willebrand factor + H2O
?
-
Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains
-
-
?
additional information
?
-
the enzyme is a hemorrhagic P-III snake venom metalloproteinase, collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases, the multidomain enzyme binds to collagen via disintegrin-like and cysteine-rich domains allocate motifs that enable catalytic degradation of extracellular matrix components leading to disruption of capillary vessels
-
-
?
additional information
?
-
the enzyme inhibits collagen-induced platelet aggregation with an IC50 value of 300 nM
-
-
?
additional information
?
-
-
possesses proteolytic and hemorrhagic activity
-
-
?
additional information
?
-
-
possesses proteolytic and hemorrhagic activity
-
-
?
additional information
?
-
-
possesses proteolytic and hemorrhagic activity
-
-
?
additional information
?
-
-
possesses proteolytic and hemorrhagic activity
-
-
?
additional information
?
-
-
in vitro induces strongly fibrinolytic activity in plasma of guinea pig, horse, dog, rabbit and human (not in plasma of rat, mouse, hamster, goat, sheep, pig or bovine), it increases tissue-type plasminogen activator activity by dissociation of a complex of this activator with type 1 plasminogen activator inhibitor and inactivation of alpha2-plasmin inhibitor
-
-
?
additional information
?
-
-
main hemorrhagic metalloproteinase in Bothrops jararaca venom
-
-
?
additional information
?
-
-
jararhagin blocks type I collagen-induced platelet aggregation by binding to the alpha2beta1 integrin and inhibiting collagen-mediated intracellular signaling events, in contrast to observation in platelets enzyme binding to the integrin receptor alpha2beta1 in fibroblasts produces collagen-like cell signaling events such as up-regulation of matrix metalloproteinase-1 and membrane-type matrix metalloproteinase-1, in fibroblasts enzyme functions as a collagen-mimetic substrate that binds to and activates integrins
-
?
additional information
?
-
-
low doses of the toxin jararhagin induce interstitial edema and increase the metabolic rate and red blood cells in Swiss mice, histology of lungs and kidney, overview, at high doses it causes hemorrhage, inflammation, necrosis and edema
-
-
?
additional information
?
-
-
the enzyme is a hemorrhagic P-III snake venom metalloproteinase
-
-
?
additional information
?
-
-
the enzyme is a P-III snake venom metalloproteinase and a potent hemorrhagin
-
-
?
additional information
?
-
-
the enzyme is a P-III snake venom metalloproteinase and a potent hemorrhagin, it causes capillary vessel basement membrane damage in vitro and in vivo, degradation of extracellular matrix components in skeletal muscle cells and endothelial cells, overview
-
-
?
additional information
?
-
-
the enzyme is a P-III snake venom metalloproteinase and a potent hemorrhagin, it induces strong pro-inflammatory response increasing the number of rolling leukocytes within capillary vessels, jararhagin induces apoptosis and release of angiostatin-like peptides in human endothelial cells, overview
-
-
?
additional information
?
-
-
the enzyme's disintegrin-like/cysteine-rich domains target it to to key extracellular matrix proteins or cell surface proteins, overview
-
-
?
additional information
?
-
-
the snake venom hemorrhagic metalloproteinase causes capillary vessel basement membrane damage in vitro and in vivo, overview
-
-
?
additional information
?
-
-
jararhagin toxin binding to collagen appears to be sufficient to inhibit collagen-induced platelet aggregation in the human host
-
-
?
additional information
?
-
-
different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to alpha2beta1 integrin, a collagen receptor, and collagen from host K-562 cells, analysis using monoclonal antibodies and recombinant jararhagin fragments, jararhagin binding to collagen and alpha2beta1 integrin occurs by two independent motifs located on disintegrin-like and cysteine-rich domains, respectively, detailed overview
-
-
?
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Mandelbaum, F.R.; Reichl, A.P.; Assakura, M.T.
Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca
Anim. Plant Microb. Toxins (Proc. Int. Symp. ,4th, Meeting Date 1974) (Ohsaka, A. , Hayashi, K. , Sawai, Y. , eds. ) Plenum Press, N. Y.
1
111-121
1976
Bothrops jararaca
-
brenda
Assakura, A.T.; Reichl, A.P.; Mandelbaum, F.R.
Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)
Toxicon
24
943-946
1986
Bothrops jararaca
brenda
Paine, M.J.I.; Desmond, H.P.; Theakston, R.D.G.; Crampton, J.M.
Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family
J. Biol. Chem.
267
22869-22876
1992
Bothrops jararaca
brenda
Sugiki, M.; Maruyama, M.; Yoshida, E.; Mihara, H.; Kamiguti, A.S.; Theakston, R.D.G.
Enhancement of plasma fibrinolysis in vitro by jararhagin, the main haemorrhagic metalloproteinase in Bothrops jararaca venom
Toxicon
33
1605-1617
1995
Bothrops jararaca
brenda
Maruyama, M.; Sugiki, M.; Yoshida, E.; Mihara, H.; Nakajima, N.
Purification and characterization of two fibrinolytic enzymes from Bothrops jararaca (jararaca) venom
Toxicon
30
853-864
1992
Bothrops jararaca
brenda
Kamiguti, A.S.; Desmond, H.P.; Theakston, R.D.G.; Hay, C.R.M.; Zuzel, M.
Ineffectiveness of the inhibition of the main haemorrhagic metalloproteinase from Bothrops jararaca venom by its only plasma inhibitor, alpha 2-macroglobulin
Biochim. Biophys. Acta
1200
307-314
1994
Bothrops jararaca
brenda
Souza, D.H.; Selistre-de-Araujo, H.S.; Moura-da-Silva, A.M.; Della-Casa, M.S.; Oliva, G.; Garratt, R.C.
Crystallization and preliminary X-ray analysis of jararhagin, a metalloproteinase/disintegrin from Bothrops jararaca snake venom
Acta Crystallogr. Sect. D
57
1135-1137
2001
Bothrops jararaca
brenda
Zigrino, P.; Kamiguti, A.S.; Eble, J.; Drescher, C.; Nischt, R.; Fox, J.W.; Mauch, C.
The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling
J. Biol. Chem.
277
40528-40535
2002
Bothrops jararaca
brenda
Tanjoni, I.; Weinlich, R.; Della-Casa, M.S.; Clissa, P.B.; Saldanha-Gama, R.F.; de Freitas, M.S.; Barja-Fidalgo, C.; Amarante-Mendes, G.P.; Moura-da-Silva, A.M.
Jararhagin, a snake venom metalloproteinase, induces a specialized form of apoptosis (anoikis) selective to endothelial cells
Apoptosis
10
851-861
2005
Bothrops jararaca
brenda
Gallagher, P.; Bao, Y.; Serrano, S.M.; Laing, G.D.; Theakston, R.D.; Gutierrez, J.M.; Escalante, T.; Zigrino, P.; Moura-da-Silva, A.M.; Nischt, R.; Mauch, C.; Moskaluk, C.; Fox, J.W.
Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin
Arch. Biochem. Biophys.
441
1-15
2005
Bothrops jararaca
brenda
Schattner, M.; Fritzen, M.; Ventura, J.d.e.S.; de Albuquerque Modesto, J.C.; Pozner, R.G.; Moura-da-Silva, A.M.; Chudzinski-Tavassi, A.M.
The snake venom metalloproteases berythractivase and jararhagin activate endothelial cells
Biol. Chem.
386
369-374
2005
Bothrops jararaca
brenda
Garcia, L.T.; Parreiras e Silva, L.T.; Ramos, O.H.; Carmona, A.K.; Bersanetti, P.A.; Selistre-de-Araujo, H.S.
The effect of post-translational modifications on the hemorrhagic activity of snake venom metalloproteinases
Comp. Biochem. Physiol. C
138
23-32
2004
Bothrops jararaca
brenda
Laing, G.D.; Paine, M.J.
Jararhagin
Handbook of Proteolytic Enzymes (Barrett,A. J. ;Rawlings,N. D. ,Woessner)
1
654-656
2004
Bothrops jararaca
-
brenda
Costa, E.P.; Santos, M.F.
Jararhagin, a snake venom metalloproteinase-disintegrin, stimulates epithelial cell migration in an in vitro restitution model
Toxicon
44
861-870
2004
Bothrops jararaca
brenda
Laing, G.D.; Moura-da-Silva, A.M.
Jararhagin and its multiple effects on hemostasis
Toxicon
45
987-996
2005
Bothrops jararaca
brenda
Clissa, P.B.; Lopes-Ferreira, M.; Della-Casa, M.S.; Farsky, S.H.; Moura-da-Silva, A.M.
Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response
Toxicon
47
591-596
2006
Bothrops jararaca
brenda
Pereira, A.L.; Fritzen, M.; Faria, F.; da Motta, G.; Chudzinski-Tavassi, A.M.
Releasing or expression modulating mediator involved in hemostasis by Berythractivase and Jararhagin (SVMPs)
Toxicon
47
788-796
2006
Bothrops jararaca
brenda
Escalante, T.; Shannon, J.; Moura-da-Silva, A.M.; Gutierrez, J.M.; Fox, J.W.
Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study
Arch. Biochem. Biophys.
455
144-153
2006
Bothrops jararaca
brenda
Pinto, A.F.; Terra, R.M.; Guimaraes, J.A.; Fox, J.W.
Mapping von Willebrand factor A domain binding sites on a snake venom metalloproteinase cysteine-rich domain
Arch. Biochem. Biophys.
457
41-46
2007
Bothrops jararaca
brenda
Moura-da-Silva, A.M.; Ramos, O.H.; Baldo, C.; Niland, S.; Hansen, U.; Ventura, J.S.; Furlan, S.; Butera, D.; Della-Casa, M.S.; Tanjoni, I.; Clissa, P.B.; Fernandes, I.; Chudzinski-Tavassi, A.M.; Eble, J.A.
Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases
Biochimie
90
484-492
2008
Bothrops jararaca (P30431)
brenda
Serrano, S.M.; Wang, D.; Shannon, J.D.; Pinto, A.F.; Polanowska-Grabowska, R.K.; Fox, J.W.
Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation
FEBS J.
274
3611-3621
2007
Bothrops jararaca
brenda
Serrano, S.M.; Kim, J.; Wang, D.; Dragulev, B.; Shannon, J.D.; Mann, H.H.; Veit, G.; Wagener, R.; Koch, M.; Fox, J.W.
The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting
J. Biol. Chem.
281
39746-39756
2006
Bothrops jararaca
brenda
Francisco, G.; Zara, F.J.; Maria, D.A.; Cruz-Neto, A.P.
Toxin jararhagin in low doses induces interstitial edema and increases the metabolic rate and red blood cells in mice
Toxicon
48
1060-1067
2006
Bothrops jararaca
brenda
Baldo, C.; Tanjoni, I.; Leon, I.R.; Batista, I.F.; Della-Casa, M.S.; Clissa, P.B.; Weinlich, R.; Lopes-Ferreira, M.; Lebrun, I.; Amarante-Mendes, G.P.; Rodrigues, V.M.; Perales, J.; Valente, R.H.; Moura-da-Silva, A.M.
BnP1, a novel P-I metalloproteinase from Bothrops neuwiedi venom: biological effects benchmarking relatively to jararhagin, a P-III SVMP
Toxicon
51
54-65
2008
Bothrops jararaca
brenda
Lambert, L.J.; Bobkov, A.A.; Smith, J.W.; Marassi, F.M.
Competitive interactions of collagen and a jararhagin-derived disintegrin peptide with the integrin alpha2-I domain
J. Biol. Chem.
283
16665-16672
2008
Bothrops jararaca
brenda
Costa, E.P.; Del Debbio, C.B.; Cintra, L.C.; da Fontoura Costa, L.; Hamassaki, D.E.; Santos, M.F.
Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells
Toxicon
52
380-384
2008
Bothrops jararaca
brenda
Tanjoni, I.; Evangelista, K.; Della-Casa, M.S.; Butera, D.; Magalhaes, G.S.; Baldo, C.; Clissa, P.B.; Fernandes, I.; Eble, J.; Moura-da-Silva, A.M.
Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to alpha2beta1 integrin and collagen
Toxicon
55
1093-1099
2010
Bothrops jararaca
brenda
Baldo, C.; Jamora, C.; Yamanouye, N.; Zorn, T.M.; Moura-da-Silva, A.M.
Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis
PLoS Negl. Trop. Dis.
4
e727
2010
Bothrops jararaca (P30431)
brenda
Klein, A.; Capitanio, J.S.; Maria, D.A.; Ruiz, I.R.
Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin
Toxicon
57
1-8
2011
Bothrops jararaca (P30431), Bothrops jararaca
brenda
Ferreira, B.A.; Deconte, S.R.; de Moura, F.B.R.; Tomiosso, T.C.; Clissa, P.B.; Andrade, S.P.; Araujo, F.A.
Inflammation, angiogenesis and fibrogenesis are differentially modulated by distinct domains of the snake venom metalloproteinase jararhagin
Int. J. Biol. Macromol.
119
1179-1187
2018
Bothrops jararaca (P30431), Bothrops jararaca
brenda
Baldo, C.; Lopes, D.S.; Faquim-Mauro, E.L.; Jacysyn, J.F.; Niland, S.; Eble, J.A.; Clissa, P.B.; Moura-da-Silva, A.M.
Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices
Toxicon
108
240-248
2015
Bothrops jararaca
brenda