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Literature summary for 3.4.24.73 extracted from

  • Baldo, C.; Jamora, C.; Yamanouye, N.; Zorn, T.M.; Moura-da-Silva, A.M.
    Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis (2010), PLoS Negl. Trop. Dis., 4, e727.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a Zn2+-dependent proteinase Bothrops jararaca

Organism

Organism UniProt Comment Textmining
Bothrops jararaca P30431
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Bothrops jararaca
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type IV collagen + H2O
-
Bothrops jararaca ?
-
?

General Information

General Information Comment Organism
physiological function jararhagin induces strong hemorrhage accompanied by hydrolysis of collagen fibers in the hypodermis and a marked degradation of type IV collagen at the vascular basement membrane. Toxin accumulation near blood vessels leads to enhanced catalysis of basement membrane components, resulting in the strong hemorrhagic activity of jararhagin Bothrops jararaca