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The expected taxonomic range for this enzyme is: Protobothrops mucrosquamatus
Reaction Schemes
Cleavage of Ser9-/-His, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr and Tyr16-/-Leu bonds in insulin B chain
Synonyms
mucrotoxin a,
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Trimeresurus metalloendopeptidase A
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Mucrotoxin A
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Cleavage of Ser9-/-His, His10-/-Leu, Ala14-/-Leu, Leu15-/-Tyr and Tyr16-/-Leu bonds in insulin B chain
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hydrolysis of peptide bond
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Ala-Leu + H2O
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Ala-Leu + H2O
Alanine + leucine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
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Dimethylcasein + H2O
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Fibrinogen + H2O
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Fibrinogen + H2O
Hydrolyzed fibrinogen
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hydrolyzes first the Aalpha and then the Bbeta chain
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Gly-Gly + H2O
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Gly-Gly + H2O
Glycine + glycine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
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Gly-Leu + H2O
Glycine + leucine
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Gly-Met + H2O
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Gly-Met + H2O
glycine + L-methionine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
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Gly-Pro + H2O
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Gly-Pro + H2O
Glycine + proline
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Gly-Tyr + H2O
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Gly-Tyr + H2O
Glycine + tyrosine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
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His-Leu + H2O
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His-Leu + H2O
Histidine + leucine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
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insulin B chain + H2O
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hydrolyzes Aalpha chain first and then the Bbeta chain
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Leu-Gly + H2O
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Leu-Gly + H2O
Leucine + glycine
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Leu-Tyr + H2O
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Leu-Tyr + H2O
Leucine + tyrosine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
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Oxidized insulin B-chain + H2O
Hydrolyzed insulin B-chain
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cleavage at Ser9-His10, His10-Leu11, Ala14-Leu15, Leu15-Tyr16 and Tyr16-Leu17
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Tyr-Leu + H2O
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Tyr-Leu + H2O
Tyrosine + leucine
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less effective than Gly-Pro, Leu-Gly or Gly-Leu
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additional information
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additional information
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no substrate: casein, exhibits lethal and hemorrhagic activity
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additional information
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no substrate: casein, exhibits lethal and hemorrhagic activity
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additional information
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produces hemorrhage in heart and stomach
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additional information
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lethal and hemorrhagic toxin
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additional information
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lethal and hemorrhagic toxin
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additional information
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does not hydrolyze casein
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additional information
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additional information
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produces hemorrhage in heart and stomach
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additional information
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lethal and hemorrhagic toxin
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additional information
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lethal and hemorrhagic toxin
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Ca2+
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metalloproteinase, contains 3 mol/mol enzyme
Mg2+
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metalloproteinase, contains 0.2 mol/mol enzyme
Zn2+
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metalloproteinase, contains 2 mol/mol enzyme
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1,10-phenanthroline
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1,10-phenanthroline
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inhibits lethal and hemorrhagic activities
Antivenin
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Antivenin
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inhibits lethal and hemorrhagic activities
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EDTA
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EDTA
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inhibits lethal and hemorrhagic activities
additional information
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no inhibition by soybean trypsin inhibitor, PCMB, diisopropylfluorophosphate
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additional information
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not inhibited by DFP, p-chloromercuribenzoate or soybean trypsin inhibitor
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additional information
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additional information
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pI: 4.3
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brenda
Chinese habu snake
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brenda
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brenda
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94000
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x * 94000, Trimeresurus mucrosquamatus, SDS-PAGE
additional information
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amino acid composition
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x * 94000, Trimeresurus mucrosquamatus, SDS-PAGE
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additional information
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no glycoprotein
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7
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10 min, 55°C, inactivation
31300
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55
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10 min, pH 7, inactivation
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from lyophilized crude venom
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to homogeneity, by gel filtraton and ion-exchange column chromatography
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medicine
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mucrolysin possesses lethal and hemorrhagic activities, induces coagulation necrosis, bleeding into various organs, especially the heart and stomach
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Sugihara, H.; Moriura, M.; Nikai, T.
Purification and properties of a lethal, hemorrhagic protein, Mucrotoxin A, from the venom of the Chinese habu snake (Trimeresurus mucrosquamatus)
Toxicon
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247-255
1983
Protobothrops mucrosquamatus
brenda
Kishida, M.; Nikai, T.; Mori, N.; Kohmura, S.; Sugihara, H.
Characterization of mucrotoxin A from the venom of Trimeresurus mucrosquamatus (the Chinese habu snake)
Toxicon
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637-645
1985
Protobothrops mucrosquamatus
brenda
Komori, Y.; Nikai, T.
Mucrolysin
Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
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705-706
2004
Protobothrops mucrosquamatus
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brenda
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3.4.24.54 mucrolysin
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