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Literature summary for 3.4.24.54 extracted from
- Mucrolysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 705-706.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | mucrolysin possesses lethal and hemorrhagic activities, induces coagulation necrosis, bleeding into various organs, especially the heart and stomach | Protobothrops mucrosquamatus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | inhibits lethal and hemorrhagic activities | Protobothrops mucrosquamatus |  |
| Antivenin | inhibits lethal and hemorrhagic activities | Protobothrops mucrosquamatus | |
| EDTA | inhibits lethal and hemorrhagic activities | Protobothrops mucrosquamatus | |
| additional information | not inhibited by DFP, p-chloromercuribenzoate or soybean trypsin inhibitor | Protobothrops mucrosquamatus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Protobothrops mucrosquamatus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, by gel filtraton and ion-exchange column chromatography | Protobothrops mucrosquamatus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Protobothrops mucrosquamatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Leu + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| Dimethylcasein + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| Fibrinogen + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| Gly-Gly + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| Gly-Met + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| Gly-Pro + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| Gly-Tyr + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| His-Leu + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| insulin B chain + H2O | hydrolyzes Aalpha chain first and then the Bbeta chain | Protobothrops mucrosquamatus | ? | - |
? | |
| Leu-Gly + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| Leu-Tyr + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
| additional information | does not hydrolyze casein | Protobothrops mucrosquamatus | ? | - |
? | |
| Tyr-Leu + H2O | - |
Protobothrops mucrosquamatus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Mucrotoxin A | - |
Protobothrops mucrosquamatus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Protobothrops mucrosquamatus |
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