Information on EC 3.4.24.45 - atrolysin F

for references in articles please use BRENDA:EC3.4.24.45
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)


The expected taxonomic range for this enzyme is: Crotalus atrox

top print hide
EC NUMBER
COMMENTARY hide
3.4.24.45
-
top print hide
RECOMMENDED NAME
GeneOntology No.
atrolysin F
-
top print hide
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cleavage of Val2-/-Asn, Gln4-/-His, Leu6-/-Cys, His10-/-Leu, Ala14-/-Leu and Tyr16-/-Leu bonds in insulin B chain
show the reaction diagram
-
-
-
-
top print hide
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
top
top print hide
CAS REGISTRY NUMBER
COMMENTARY hide
172306-52-4
-
top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
top print hide
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Basement membrane preparation + H2O
?
show the reaction diagram
-
-
-
-
-
Basement membranes surrounding capillaries + H2O
?
show the reaction diagram
casein + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen IV + H2O
?
show the reaction diagram
-
basement membrane component
-
-
-
Dimethylcasein + H2O
?
show the reaction diagram
Fibrinogen + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrinogen + H2O
Hydrolyzed fibrinogen
show the reaction diagram
Fibronectin + H2O
?
show the reaction diagram
-
-
-
-
-
Gelatin of collagen type I + H2O
?
show the reaction diagram
-
-
-
-
-
Gelatin of collagen type III + H2O
?
show the reaction diagram
-
-
-
-
-
Gelatin of collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
-
Laminin + H2O
?
show the reaction diagram
-
basement membrane component
-
-
-
Nidogen + H2O
?
show the reaction diagram
-
basement membrane component
-
-
-
Oxidized insulin B-chain + H2O
?
show the reaction diagram
-
-
-
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed oxidized insulin B-chain
show the reaction diagram
additional information
?
-
top print hide
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Basement membranes surrounding capillaries + H2O
?
show the reaction diagram
top print hide
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
top print hide
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
top print hide
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
top print hide
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
top print hide
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
top print hide
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
amino acid composition, immunologically not related to hemorrhagic toxin a or c
top print hide
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
top print hide
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
no glycoprotein
-
-
top print hide
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
from lyophilized crude venom
-
ion-exchange chromatography and gel filtration
-
top print hide
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
top print hide
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
second-most potent hemorrhagic toxin of all the atrolysins, systemic hemorrhage in lung, kidney, liver, heart, destruction of muscle tissue
top
top
LINKS TO OTHER DATABASES (specific for EC-Number 3.4.24.45)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)