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Literature summary for 3.4.24.45 extracted from

  • Fox, J.W.; Bjarnason, J.B.
    Atrolysins: metalloproteinases from Crotalus atrox venom (1995), Methods Enzymol., 248, 368-387.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Crotalus atrox

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Crotalus atrox
EDTA
-
Crotalus atrox

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloproteinase, 1 mol zinc/mol enzyme Crotalus atrox

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
1 * 64000, Crotalus atrox, SDS-PAGE Crotalus atrox

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Basement membranes surrounding capillaries + H2O Crotalus atrox involved in disruption of capillary membranes ?
-
?
Basement membranes surrounding capillaries + H2O Crotalus atrox together with atrolysin A member of the class P-III hemorrhagic toxins ?
-
?

Organism

Organism UniProt Comment Textmining
Crotalus atrox
-
Western diamondback rattlesnake
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein
-
Crotalus atrox

Purification (Commentary)

Purification (Comment) Organism
from lyophilized crude venom Crotalus atrox

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Crotalus atrox
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Basement membrane preparation + H2O
-
Crotalus atrox ?
-
?
Basement membranes surrounding capillaries + H2O involved in disruption of capillary membranes Crotalus atrox ?
-
?
Basement membranes surrounding capillaries + H2O together with atrolysin A member of the class P-III hemorrhagic toxins Crotalus atrox ?
-
?
Collagen IV + H2O basement membrane component Crotalus atrox ?
-
?
Fibrinogen + H2O cleaves gamma-chain, Aalpha and Bbeta-chains remain intact Crotalus atrox Hydrolyzed fibrinogen
-
?
Fibronectin + H2O
-
Crotalus atrox ?
-
?
Gelatin of collagen type I + H2O
-
Crotalus atrox ?
-
?
Gelatin of collagen type III + H2O
-
Crotalus atrox ?
-
?
Gelatin of collagen type IV + H2O
-
Crotalus atrox ?
-
?
Laminin + H2O basement membrane component Crotalus atrox ?
-
?
additional information
-
Crotalus atrox ?
-
?
Nidogen + H2O basement membrane component Crotalus atrox ?
-
?
Oxidized insulin B-chain + H2O
-
Crotalus atrox Hydrolyzed oxidized insulin B-chain
-
?

Subunits

Subunits Comment Organism
monomer 1 * 64000, Crotalus atrox, SDS-PAGE Crotalus atrox

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
pI: 7.7 Crotalus atrox