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Ac-DEVD-7-amido-4-methylcoumarin + H2O
Ac-DEVD + 7-amino-4-methylcoumarin
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acetyl-ASTD-7-amido-4-methylcoumarin + H2O
acetyl-ASTD + 7-amino-4-methylcoumarin
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acetyl-DEVD-7-amido-4-methylcoumarin + H2O
acetyl-DEVD + 7-amino-4-methylcoumarin
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inhibitor of caspase-actived DNase + H2O
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mouse caspase-7 and caspase-3 are equally efficient at cleaving
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pro-endothelial monocyte-activating polypeptide II + H2O
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caspase-7-mediated generation and release of mature endothelial monocyte-activating polypeptide II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation
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pro-endothelial monocyte-activating polypeptide II + H2O
endothelial monocyte-activating polypeptide II + ?
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pro-endothelial monocyte-activating polypeptide II in which the ASTD cleavage site is changed to the sequence ASTA, is not processed by caspase-7
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additional information
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additional information
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overexpression induces apoptosis
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additional information
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caspase-7 is involved in apoptosis
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additional information
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intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages
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additional information
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members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis, the major executioner caspases are caspase-3 and caspase-7, which show overlapping substrate specificities, overview
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additional information
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the apoptotic executioner caspase-7 is activated in the splenocytes of lipopolysaccharide-injected mice, suggesting a role for caspase-7 in lymphocyte apoptosis. Caspase-7 deficiency and caspase inhibition protect from endotoxin-induced lymphocyte apoptosis and improve survival
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Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P55210), Mus musculus (P97864)
brenda
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
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Mus musculus (P97864)
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Juan, T.S.C.; McNiece, I.K.; Argento, J.M.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Fletcher, F.A.
Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3
Genomics
40
86-93
1997
Homo sapiens (P55210), Homo sapiens, Mus musculus (P97864), Mus musculus
brenda
Behrensdorf, H.A.; van de Craen, M.; Knies, U.E.; Vandenabeele, P.; Clauss, M.
The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7
FEBS Lett.
466
143-147
2000
Mus musculus
brenda
Houde, C.; Banks, K.G.; Coulombe, N.; Rasper, D.; Grimm, E.; Roy, S.; Simpson, E.M.; Nicholson, D.W.
Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice
J. Neurosci.
24
9977-9984
2004
Homo sapiens, Mus musculus
brenda
Lamkanfi, M.; Moreira, L.O.; Makena, P.; Spierings, D.C.; Boyd, K.; Murray, P.J.; Green, D.R.; Kanneganti, T.D.
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival
Blood
113
2742-2745
2009
Mus musculus
brenda
Jen, C.Y.; Lin, C.Y.; Leu, S.F.; Huang, B.M.
Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis through caspase-9 pathway
Evid. Based. Complement Alternat. Med.
2009
1-10
2009
Mus musculus
brenda
Akhter, A.; Gavrilin, M.A.; Frantz, L.; Washington, S.; Ditty, C.; Limoli, D.; Day, C.; Sarkar, A.; Newland, C.; Butchar, J.; Marsh, C.B.; Wewers, M.D.; Tridandapani, S.; Kanneganti, T.D.; Amer, A.O.
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
PLoS Pathog.
5
e1000361
2009
Mus musculus, Mus musculus C57BL/6
brenda
Walsh, J.G.; Cullen, S.P.; Sheridan, C.; Luethi, A.U.; Gerner, C.; Martin, S.J.
Executioner caspase-3 and caspase-7 are functionally distinct proteases
Proc. Natl. Acad. Sci. USA
105
12815-12819
2008
Homo sapiens, Mus musculus
brenda
Matalova, E.; Vanden Berghe, T.; Svandova, E.; Vandenabeele, P.; Healy, C.; Sharpe, P.T.; Tucker, A.S.
Caspase-7 in molar tooth development
Arch. Oral Biol.
57
1474-1481
2012
Mus musculus
brenda
Brentnall, M.; Rodriguez-Menocal, L.; De Guevara, R.L.; Cepero, E.; Boise, L.H.
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
BMC Cell Biol.
14
32
2013
Mus musculus
brenda
Svandova, E.; Lesot, H.; Vanden Berghe, T.; Tucker, A.S.; Sharpe, P.T.; Vandenabeele, P.; Matalova, E.
Non-apoptotic functions of caspase-7 during osteogenesis
Cell Death Dis.
5
e1366
2014
Mus musculus
brenda
Matalova, E.; Lesot, H.; Svandova, E.; Vanden Berghe, T.; Sharpe, P.T.; Healy, C.; Vandenabeele, P.; Tucker, A.S.
Caspase-7 participates in differentiation of cells forming dental hard tissues
Dev. Growth Differ.
55
615-621
2013
Mus musculus
brenda
Cassidy, S.K.; Hagar, J.A.; Kanneganti, T.D.; Franchi, L.; Nunez, G.; ORiordan, M.X.
Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response
PLoS Pathog.
8
e1002628
2012
Mus musculus
brenda