EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.60 | C186S |
site-directed mutagenesis |
701085 |
| 3.4.22.60 | C285A |
mutant procaspase-7 shows no autoactivation |
647666 |
| 3.4.22.60 | C290N |
molecular dynamics simulation, changes in catalytic activity upon mutation are reflected in corresponding changes in the global dynamics |
754207 |
| 3.4.22.60 | D198A |
additionally, amino acid residues 20-25 are replaced with a thrombin cleavage site (LVPRGS) and a thrombin cleavage site (LVPRGS) is inserted between Asp-203 and Thr-204 |
710479 |
| 3.4.22.60 | D23A |
the mutation shows increased catalytic activity but is unable to cleave PARP |
732814 |
| 3.4.22.60 | D628A |
site-directed mutagenesis, caspase-7 resistant mutant, retains telomerase activity |
717260 |
| 3.4.22.60 | E286A |
site-directed mutagenesis, inactive mutant |
717260 |
| 3.4.22.60 | E286A/D628A |
site-directed mutagenesis, inactive mutant |
717260 |
| 3.4.22.60 | G188L |
molecular dynamics simulation, changes in catalytic activity upon mutation are reflected in corresponding changes in the global dynamics |
754207 |
| 3.4.22.60 | G188P |
molecular dynamics simulation, changes in catalytic activity upon mutation are reflected in corresponding changes in the global dynamics |
754207 |
